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usepigskinThe cornea can restore the vision of visually impaired patients.

really？ ? ?

Yes, this study was recently published in Nature Biotechnology, a sub-journal of Nature, and a pilot study has been carried out, which has restored the vision of 20 patients without adverse reactions.

In the world, there are as many as 12.7 million people who are sick or even blind because of corneal damage. At present, the most common method is to transplant corneas donated by human beings, but only one in every 70 patients can get a corneal transplant.

Moreover, patients who need corneal transplantation often gather in low-income and middle-income countries or regions, and the opportunities for treatment are very limited.

At this time, the pig came, and the pig came with its powerful effect.

However, when it comes to pigskin, few people associate it with cornea. How are they related?

Using collagen molecules from pigskin

One of the main components of cornea is collagen. By extracting collagen molecules from pigskin, researchers developed a collagen-based corneal matrix substitute: Bioengineered Porcine Construction (Double Crosslinked for short: BPCDX).

How exactly is it done?

Firstly, after extracting collagen from pigskin, it was purified and freeze-dried.

Collagen was then dissolved in sterile phosphate buffered saline (PBS) at room temperature to form a 5% collagen solution.

Next, a new vacuum evaporation technology is used, which can controllably achieve high collagen content (12-18%). In the past, the weight of collagen in human test implants was limited to 10% (the natural human corneal collagen content was 13.6%).

However, pure collagen is a soft material which is easy to degrade. In order to solve this problem, researchers used two chemical crosslinks to finally form a transparent implantable hydrogel, which improved the mechanical strength, degradation resistance and long-term stability of the implant.

But is it reliable to use pigskin to make cornea and treat visually impaired patients?

In this regard, the researchers also conducted a series of clinical trials, and they conducted feasibility studies in India and Iran.

The researchers implanted BPCDX in 20 visually impaired patients to reshape the native corneal stroma without removing existing tissues or using sutures.

During the two-year follow-up, no adverse phenomena were observed.

As can be seen from the table, 14 legally blind people before operation were not judged to be blind after operation. Moreover, all subjects in the two queues were intolerant of contact lenses before operation, but they could tolerate wearing contact lenses for a long time at 24 months after operation.

Judging from the effect of clinical trial, this is not an unreliable technology, but it sounds very complicated. Can ordinary patients afford it?

Low cost, easy storage and minimally invasive.

Mehrdad Rafat, an associate professor of biomedical engineering, said:

We do a lot of research to ensure that this technology is affordable for everyone, not just the rich.

In this technology, pigskin used in extracting collagen is a by-product of food industry, which is easy to obtain and the cost is not very high.

In addition, researchers have developed compatible packaging and sterilization processes, so that bioengineered corneas can be stored for up to two years before use, so that they can be provided to different regions and even rural areas without biological banks or storage tissue preparation facilities.

It is worth mentioning that the cornea made of pigskin does not need to remove the patient’s own tissue when treating visually impaired patients, but instead, it is a small incision through which the implant is inserted into the existing cornea.

And this new surgical method does not need suture, but uses advanced laser surgery to make corneal incision with high precision, and then uses simple surgical instruments to perform it manually when necessary.

It costs less and is minimally invasive, so when will this technology be popularized?

Not yet!

Before using implants in medical care, it is necessary to conduct larger-scale clinical research and obtain market approval from regulatory agencies.

In addition, researchers also want to study whether this technology can be used to treat more eye diseases, and whether implants can be adapted to individuals to obtain greater curative effects.

One More Thing

In fact, in 2016, there was a successful case of bioengineered corneal transplantation in South China. A 14-year-old boy from Jiangxi chose bioengineered membrane transplantation. After a week of treatment, his vision reached 0.1.

However, this operation uses a rarer pig cornea, and this study of Nature is to extract collagen from pig skin to make a corneal substitute. In contrast, the latter has greater application potential.

　　Xinhua News Agency, Beijing, January 11th　

Opinions of the Central Committee of the Communist Party of China and the State Council on comprehensively promoting the construction of beautiful China

(December 27, 2023)

　　Building a beautiful China is an important goal of building a socialist modern country in an all-round way and an important content of realizing the Chinese nation’s great rejuvenation of the Chinese dream. In order to comprehensively promote the construction of beautiful China and accelerate the modernization of harmonious coexistence between man and nature, the following opinions are put forward.

　　First, a new era and a new journey have begun to comprehensively promote a new chapter in the construction of beautiful China

　　Since the 18th National Congress of the Communist Party of China, the CPC Central Committee with the Supreme Leader as the core has placed the construction of ecological civilization in a prominent position in its overall work, strengthened the protection of ecological environment in all directions, regions and the whole process, and achieved a major shift from key remediation to systematic governance, from passive response to active action, from participants to leaders in global environmental governance, and from practical exploration to scientific theory guidance. Great strides have been made in the construction of beautiful China.

　　At present, China’s economic and social development has entered a high-quality development stage of accelerating greening and low carbonization. The construction of ecological civilization is still in a critical period of pressure superposition and carrying forward. The structural, root and trend pressures of ecological environmental protection have not been fundamentally alleviated. The endogenous motivation for green transformation of economic and social development is insufficient, and the foundation for stable and good ecological environment quality is still not solid. The degradation trend of some regional ecosystems has not been fundamentally reversed, and the task of building a beautiful China is still arduous. On the new journey, we must put the construction of beautiful China in a prominent position in the construction of a strong country and national rejuvenation, maintain the strategic determination to strengthen the construction of ecological civilization, unswervingly follow the road of civilized development with production development, affluent life and good ecology, and build a beautiful home with sky blue, green land and clear water.

　　Second, the overall requirements

　　To comprehensively promote the construction of a beautiful China, we must adhere to the guidance of the Supreme Leader’s New Era Socialism with Chinese characteristics Thought, especially the Supreme Leader’s Ecological Civilization Thought, thoroughly implement the spirit of the 20th Party Congress, implement the deployment of the National Ecological Environmental Protection Conference, and firmly establish and practice the concept of Lucid waters and lush mountains are invaluable assets. Deal with the relationship between high-quality development and high-level protection, key tackling and collaborative governance, natural restoration and artificial restoration, external constraints and endogenous power, "double carbon" commitment and independent action, coordinate industrial structure adjustment, pollution control, ecological protection, and respond to climate change, jointly promote carbon reduction, pollution reduction, greening and growth, safeguard national ecological security, do a good job in system of ecological civilization construction, support high-quality development with high-quality ecological environment, and accelerate the formation of people.

　　The main objectives are: by 2027, the development of green and low carbon will be further promoted, the total discharge of major pollutants will be continuously reduced, the quality of ecological environment will be continuously improved, the pattern of land space development and protection will be optimized, the service function of ecosystem will be continuously enhanced, the urban and rural living environment will be significantly improved, the national ecological security will be effectively guaranteed, the ecological environment governance system will be more perfect, and a number of practical models will be formed. The construction of beautiful China has achieved remarkable results. By 2035, a green production and lifestyle will be widely formed, carbon emissions will stabilize and decrease after reaching the peak, the ecological environment will be fundamentally improved, a new pattern of land space development and protection will be fully formed, the stability of ecosystem diversity will be significantly improved, the national ecological security will be more stable, the modernization of ecological environment governance system and governance capacity will be basically realized, and the goal of beautiful China will be basically realized. Looking forward to the middle of this century, the ecological civilization will be improved in an all-round way, the green development mode and lifestyle will be fully formed, the key areas will be deeply decarbonized, the ecological environment will be healthy and beautiful, the ecological environment governance system and governance capacity will be fully modernized, and the beautiful China will be fully built.

　　Anchor the construction goal of beautiful China, adhere to precise pollution control, scientific pollution control, and pollution control according to law. According to the new demand of high-quality economic and social development and the people’s new expectations for ecological environment improvement, we will intensify the centralized solution of outstanding ecological environment problems and accelerate the improvement of ecological environment quality from quantitative to qualitative. During the 14th Five-Year Plan period, we made a thorough attack to achieve continuous improvement of the ecological environment. Consolidate and expand in the Tenth Five-Year Plan to achieve an overall improvement of the ecological environment; The overall improvement of the "Sixteenth Five-Year Plan" will achieve a fundamental improvement in the ecological environment. We must persist in:

　　— — All-field transformation. Vigorously promote green and low-carbon economic and social development, accelerate green and low-carbon transformation in energy, industry, transportation, urban and rural construction, agriculture and other fields, strengthen green scientific and technological innovation, and enhance the endogenous power and innovation vitality of beautiful China construction.

　　— — All-round promotion. Adhere to the overall planning of factors and the integration of urban and rural areas, carry out the construction of "Beautiful Series" as a whole, focus on promoting the construction of beautiful blue sky, beautiful rivers and lakes, beautiful bays and beautiful mountains and rivers, create a beautiful China pioneer area, this beautiful city and beautiful countryside, and draw a beautiful new picture of China.

　　— — All-regional construction. According to local conditions, we will promote the global coverage of the construction of beautiful China step by step, show the magnificent scenery in the western part of Damei, the vast scenery in the northeast, the beautiful mountains and rivers in the central part and the beautiful charm in the harmonious east, and create a unique and colorful beautiful China construction plate.

　　— — Action of the whole society. Turn the construction of beautiful China into the behavior consciousness of all people, and encourage grass-roots units such as parks, enterprises, communities and schools to carry out green, clean and zero-carbon leading actions, so as to form a good social atmosphere for everyone to participate and share.

　　Third, accelerate the green transformation of development mode

　　(1) Optimize the pattern of land space development and protection. Improve the system of main functional areas, improve the system of land spatial planning, and optimize the spatial layout of agriculture, ecology, cities and towns as a whole. Adhere to the red line of ecological protection, strengthen law enforcement supervision and protection and restoration, so that the red line area of ecological protection in the country will remain above 3.15 million square kilometers. Resolutely hold the red line of 1.8 billion mu of cultivated land to ensure that the cultivated land that can be used stably for a long time will not be reduced. Strictly control the boundaries of urban development and promote the intensive green development of urban space. Strictly control the shoreline space of rivers and lakes. Strengthen the control of marine and coastal land space, establish an exit mechanism for inefficient sea use, and no new reclamation will be added except for major national projects. Improve the ecological environment zoning control system covering the whole area, in order to develop "clear the bottom line" and "draw the border". By 2035, the retention rate of natural coastline on the mainland will not be less than 35%, and the ecological function and nature of the red line of ecological protection will not be reduced.

　　(2) Actively and steadily promote carbon neutrality in peak carbon dioxide emissions. Peak carbon dioxide emissions Action will be implemented in a planned and step-by-step manner, so as to achieve peak carbon dioxide emissions by 2030 and lay the foundation for carbon neutrality by 2060. Insist on establishing first and then breaking, accelerate the planning and construction of a new energy system, and ensure energy security. Focus on controlling the consumption of fossil energy such as coal, strengthen the clean and efficient utilization of coal, vigorously develop non-fossil energy, and accelerate the construction of new power systems. We will carry out multi-field and multi-level collaborative innovation pilot projects to reduce pollution and carbon. Promote the dual control of energy consumption to gradually shift to the dual control of total carbon emissions and intensity, and strengthen the basic capacity and system construction of dual control of carbon emissions. Prepare the national greenhouse gas inventory year by year. Implement the methane emission control action plan, and study and formulate other non-carbon dioxide greenhouse gas emission control action plans. Further develop the national carbon market, steadily expand the industry coverage, enrich the trading varieties and methods, and build and improve the national voluntary greenhouse gas emission reduction trading market. By 2035, the proportion of non-fossil energy in total energy consumption will further increase, and a more effective, dynamic and internationally influential carbon market will be built.

　　(3) Make overall plans to promote green and low-carbon development in key areas. Promote the deep integration of digital and intelligent industries with greening, accelerate the construction of a modern industrial system supported by the real economy, and vigorously develop strategic emerging industries, high-tech industries, green environmental protection industries and modern service industries. Strictly control the access barrier and resolutely curb the blind launch of projects with high energy consumption, high emissions and low level. Vigorously promote the upgrading of traditional industries’ processes, technologies and equipment, realize green and low-carbon transformation, and implement the cleaner production level improvement project. Accelerate the energy-saving and carbon-reducing transformation of existing buildings and municipal infrastructure, and promote the large-scale development of ultra-low energy consumption and low-carbon buildings. Vigorously promote "revolving iron" and "revolving water", speed up the construction of special railway lines, and improve the level of clean transportation of bulk goods. We will promote the green transformation of railway stations, civil airports, ports and docks, logistics parks and other railway electrification transformation, and promote the large-scale application of ultra-low and near-zero emission vehicles and the clean and low-carbon application of off-road mobile machinery. By 2027, the proportion of new energy vehicles among new vehicles will strive to reach 45%, the old diesel locomotives will be basically eliminated, and the port container hot metal combined transport volume will maintain rapid growth; By 2035, the railway freight turnover will account for about 25% of the total turnover.

　　(4) Promoting the economical and intensive utilization of various resources. Implement a comprehensive saving strategy to promote energy saving, water saving, land saving, material saving and mine saving. We will continue to deepen energy conservation in key areas and strengthen energy management in new infrastructure. In-depth implementation of the national water-saving action, strengthen the dual control of total water consumption and intensity, improve the water efficiency of key water-using industries and products, actively promote the utilization of sewage resources, and strengthen the allocation and utilization of unconventional water sources. Improve the system of economical and intensive land use, and popularize land-saving technologies and models. Establish green manufacturing system and service system. Carry out comprehensive utilization of resources to improve quality and efficiency. Accelerate the construction of waste recycling system, and promote the recycling of waste fan blades, photovoltaic modules, power batteries, express packaging and other wastes. Promote the conservation of raw materials and recycling of resources, and vigorously develop the remanufacturing industry. Comprehensively promote the construction of green mines. By 2035, the utilization efficiency of energy and water resources will reach the international advanced level.

　　Fourth, continue to deepen the fight against pollution.

　　(5) continue to fight the blue sky defense war in depth. Taking Beijing-Tianjin-Hebei and its surrounding areas, the Yangtze River Delta, Fenwei Plain and other key areas as the main battlefield, and taking the control of fine particles as the main line, we will vigorously promote the coordinated emission reduction of multiple pollutants. Strengthen the comprehensive management of volatile organic compounds and implement the source substitution project. High-quality promotion of ultra-low emission transformation of key industries such as steel, cement and coking and coal-fired boilers. Take measures such as clean energy and central heating substitution according to local conditions, and continue to promote pollution control of loose coal, coal-fired boilers and industrial furnaces. Continuous implementation of total coal consumption control in key areas. Study and formulate motor vehicle emission standards in the next stage, carry out research on oil quality standards in the new stage, and strengthen joint supervision and law enforcement by departments. Strengthen regional joint defense and control, and deepen the performance grading of key industries in heavily polluted weather. Continue to implement noise pollution prevention and control actions. Efforts will be made to solve pollution problems such as stench and catering fumes. Strengthen environmental management of ozone-depleting substances and hydrofluorocarbons. By 2027, the national average concentration of fine particles will drop below 28 μ g/m3, and cities at and above the local level will strive to meet the standards; By 2035, the concentration of fine particles in China will drop below 25 μ g/m3, and the air will always be fresh and the blue sky will always be there.

　　(6) Continue to fight the battle for clear water. Coordinate the management of water resources, water environment and water ecology, further promote the protection and management of major rivers and lakes such as the Yangtze River and the Yellow River, and optimize and adjust the water function zoning and management system. Solidly promote the standardized construction of water sources and the construction of standby water sources. Basically complete the investigation and rectification of sewage outlets entering the river and the sea, and comprehensively build a monitoring and supervision system for sewage outlets. Implement performance classification of sewage treatment and discharge level of enterprises in key industries. We will speed up the completion of the shortcomings of urban sewage collection and treatment facilities, build a model area with full coverage of urban sewage pipe network, strengthen the harmless treatment and resource utilization of sludge, and build a green and low-carbon benchmark factory for sewage treatment. Carry out endogenous pollution control and ecological restoration according to local conditions, basically eliminate black and odorous water bodies in urban and rural areas and form a long-term mechanism. Establish a water ecological assessment mechanism, strengthen the protection and restoration of water conservation areas and ecological buffer zones, strengthen the unified dispatch of water resources, and ensure the ecological flow of rivers and lakes. Adhere to the overall planning of land and sea, river and sea linkage, and continue to promote comprehensive management of key sea areas. Taking the bay as the basic unit, "one bay and one policy" will jointly promote pollution prevention and control in coastal waters, ecological protection and restoration, and coastal environment improvement, and continuously improve the quality and stability of important marine ecosystems such as mangroves. Strengthen the improvement of mariculture environment. Actively respond to ecological disasters such as cyanobacteria blooms and red tides. Promote the cleaning of rivers, lakes and reservoirs and the treatment of marine garbage. By 2027, the excellent proportion of surface water quality and coastal water quality in China will reach about 90% and 83% respectively, and the completion rate of beautiful rivers, lakes and beautiful bays will reach about 40%;By 2035, beautiful rivers and lakes and beautiful bays with "harmony between people and water" will be basically completed.

　　(7) Continue to fight the battle for the pure land. Carry out prevention and control actions at the source of soil pollution, prevent new pollution, and gradually solve the serious pollution problem of soil and groundwater accumulated for a long time. Strengthen the protection of priority protected cultivated land, solidly promote the safe use and risk control of contaminated cultivated land, and promote the traceability and remediation of heavy metal pollution in agricultural land by stages. Strengthen the joint supervision of the change of construction land use and the risk management and control of contaminated plots in accordance with the law, and promote the risk management and control and restoration of large-scale contaminated sites. Comprehensive monitoring of soil and groundwater environment around key soil pollution supervision units will be carried out, and the second national soil pollution survey will be carried out in due course. Carry out national investigation and evaluation of groundwater pollution, strengthen environmental protection of groundwater drinking water sources, and strictly control environmental risks in key areas for groundwater pollution prevention and control. Deepen the fight against pollution in agriculture and rural areas. By 2027, the safe utilization rate of polluted farmland will reach over 94%, and the safe utilization of construction land will be effectively guaranteed; By 2035, the proportion of Class I-IV water in the state-controlled points of groundwater will reach over 80%, and the soil environmental risks will be fully controlled.

　　(eight) to strengthen the management of solid waste and new pollutants. Accelerate the construction of a "waste-free city", continue to promote the action of controlling new pollutants, and promote the realization of "waste-free" and environmental health in urban and rural areas. Strengthen the comprehensive management of solid waste, limit excessive packaging of commodities, and control plastic pollution through the whole chain. We will deepen the comprehensive ban on the entry of "foreign garbage" and strictly guard against the smuggling and disguised import of various forms of solid waste. Strengthen the supervision, utilization and disposal capacity of hazardous wastes, and strengthen the pollution control of tailings ponds with emphasis on the Yangtze River Economic Belt and the Yellow River Basin. Formulate regulations on environmental risk management of toxic and harmful chemicals. By 2027, the proportion of "waste-free cities" will reach 60%, and the intensity of solid waste production will drop significantly; By 2035, the construction of a "waste-free city" will achieve full coverage, and the eastern provinces will take the lead in building a "waste-free city" in the whole region, and the environmental risks of new pollutants will be effectively controlled.

　　V. Enhancing the stability and sustainability of ecosystem diversity

　　(9) Build a strong natural ecological barrier. Stabilize the national ecological security barrier and promote the protection and construction of national key ecological function area and important ecological corridors. Comprehensively promote the construction of nature reserves system with national parks as the main body, and complete the integration and optimization of nature reserves throughout the country. Implement the national natural ecological resources monitoring, evaluation and early warning project. Strengthen the construction of ecological protection and restoration supervision system and strengthen unified supervision. Strictly supervise the owners, developers and even supervisors, discover and investigate all kinds of ecological damage events in time, and resolutely put an end to formalism in ecological restoration. Strengthen the monitoring and evaluation of ecological conditions and carry out the effectiveness evaluation of ecological protection and restoration. We will continue to strengthen the supervision of the "Green Shield" nature reserve and establish a supervision mechanism for the ecological damage of the red line of ecological protection. By 2035, the national park system will be basically completed, the ecosystem pattern will be more stable, and the beautiful mountains and rivers will be full of vitality.

　　(ten) the implementation of landscape, forest, field, lake, grass and sand integrated protection and systematic management. Accelerate the implementation of major projects for the protection and restoration of important ecosystems, and promote grassland forests, rivers, lakes and wetlands to recuperate. Continue to implement the integrated protection and restoration project of mountains, rivers, forests, fields, lakes, grass and sand. Scientifically carry out large-scale land greening operations, increase the protection and restoration of grasslands and wetlands, strengthen the comprehensive management of desertification, rocky desertification and soil erosion, fully implement sustainable forest management, and strengthen fire prevention and extinguishing in forests and grasslands. Focus on the sand sources and transmission routes that affect key areas such as Beijing, continue to promote the construction of the "Three North" project and the control of sandstorms in Beijing and Tianjin, and make every effort to fight the three landmark battles. Promote the consolidation and improvement of the carbon sink capacity of the ecosystem. By 2035, the national forest coverage rate will increase to 26%, the soil and water conservation rate will increase to 75%, and the ecosystem will basically achieve a virtuous circle.

　　(eleven) to strengthen the protection of biodiversity. Strengthen the overall coordination role of the coordination mechanism for biodiversity conservation, implement the "Kunming-Montreal Global Biodiversity Framework", update the biodiversity conservation strategy and action plan of China, and implement major biodiversity conservation projects. Improve the national biodiversity protection network, comprehensively protect wild animals and plants, and gradually establish a national botanical garden system. We will further promote the rescue of rare and endangered species in the Yangtze River and continue to implement the ten-year fishing ban measures in the Yangtze River. Fully implement the system of closed fishing in summer and build a modern marine pasture. By 2035, the land area of national nature reserves will account for no less than 18% of the land area, and typical ecosystems, national key protected wildlife and their habitats will be fully protected.

　　Sixth, keep the beautiful China construction safety bottom line.

　　(12) Improve the national ecological security system. Implement the overall national security concept, improve the coordination mechanism of national ecological security work, strengthen cooperation with economic security, resource security and other fields, improve the national ecological security legal system, strategic system, policy system and response management system, enhance the national ecological security risk assessment, monitoring and early warning, emergency response and disposal capabilities, and form a global linkage, three-dimensional and efficient national ecological security protection system.

　　(thirteen) to ensure nuclear and radiation safety. Strengthen the overall role of the national nuclear safety coordination mechanism, build a strict nuclear safety responsibility system, comprehensively improve the nuclear safety supervision ability, build a modern nuclear safety supervision system that is suitable for the development of China’s nuclear industry, and promote the high-quality development of nuclear safety. Strengthen the safety management of the first and new reactors, regularly carry out safety evaluation of operating facilities and continuously implement improvement, speed up the decommissioning of old facilities and the treatment and disposal of radioactive waste left over from history, and strengthen the safety management of nuclear technology utilization and electromagnetic radiation environment management. Strengthen the monitoring and research of marine radiation environment in the sea areas under our jurisdiction, and improve the risk early warning and monitoring and emergency response capabilities. Adhere to independent innovation and safe development, and strengthen key and basic scientific and technological research and development and intelligent safety management in the field of nuclear safety.

　　(fourteen) to strengthen the management of biological safety. Strengthen the environmental risk detection, identification, evaluation and monitoring of biotechnology and its products. Strengthen the whole chain prevention and control and system governance, and improve the biosafety supervision and early warning prevention and control system. Strengthen pest control. Carry out general survey, monitoring, early warning and impact assessment of alien invasive species, and strengthen quarantine of imported animals and plants and prevention and control of alien invasive species. Improve the protection and utilization system of germplasm resources and strengthen the protection and management of biological genetic resources.

　　(fifteen) to effectively deal with the adverse effects and risks of climate change. Adhere to both mitigation and adaptation, and vigorously enhance the ability to adapt to climate change. Strengthen the construction of climate change observation network, and strengthen monitoring, forecasting and early warning and impact risk assessment. Continue to improve the climate resilience in agriculture, health and public health, and strengthen the climate risk management of infrastructure and major projects. Deepen the construction of climate-adapted cities, promote the construction of sponge cities, and strengthen regional actions to adapt to climate change. By 2035, a climate-adaptive society will be basically completed.

　　(sixteen) strict prevention and control of environmental risks. Adhere to prevention and strengthen the normalization management of environmental risks. Improve the national environmental emergency system and mechanism, improve the environmental emergency responsibility system with hierarchical responsibility, territorial priority and departmental coordination, and improve the upstream and downstream and cross-regional emergency linkage mechanism. Strengthen the investigation and risk prevention and control of environmental hazards in key areas such as hazardous wastes, tailings ponds and heavy metals, as well as jurisdictional sea areas and border areas. We will implement a number of environmental emergency basic capacity-building projects, establish and improve the emergency response system and emergency material reserve system, improve the information level of environmental emergency command, and properly and scientifically handle various environmental emergencies in a timely manner. Improve the environmental health monitoring, investigation and risk assessment system.

　　Seven, to create a beautiful China construction demonstration model.

　　(seventeen) the construction of beautiful China pioneer area. Focus on regional coordinated development strategies and major regional strategies, strengthen green development cooperation, and create a green development highland. Improve the coordinated protection mechanism of ecological environment in Beijing-Tianjin-Hebei region, accelerate the construction of demonstration areas for ecological environment restoration and improvement, and promote xiong’an new area to build a model of green development city. In the in-depth implementation of the development strategy of the Yangtze River Economic Belt, we insist on joint protection and build a green development demonstration belt with harmonious coexistence between man and nature. Deepen the connection of rules and mechanisms in the field of ecological environment in Guangdong-Hong Kong-Macao Greater Bay Area, and build a world-class Meiliwan District. Deepen the innovation of joint insurance, joint governance and integration system in the Yangtze River Delta region and build a beautiful Yangtze River Delta at a high level. Adhere to water to determine the city, land, people and production, and build a pioneering area for ecological protection and high-quality development in the Yellow River Basin. Deepen the construction of the national ecological civilization experimental zone. Based on the regional functional orientation, each region gives full play to its own characteristics and writes a provincial chapter on the construction of beautiful China.

　　(eighteen) the construction of this beautiful city. Adhere to the people’s city, the people’s city for the people, and promote the construction of this beautiful city with green and low carbon, beautiful environment, ecological livability, safety, health, wisdom and efficiency. Improve the level of urban planning, construction and governance, implement urban renewal actions, and strengthen inter-city and urban-rural ecological protection and environmental governance. Accelerate the transformation of the development mode of megacities, improve the efficiency of ecological environment management in large and medium-sized cities, promote the upgrading and capacity expansion of environmental infrastructure in small and medium-sized cities and counties, and promote the ability of environmental public services to adapt to the population and economic scale. Carry out urban ecological environment governance assessment.

　　(nineteen) the construction of beautiful countryside. Promote the experience of Zhejiang’s "Ten Million Projects" according to local conditions, and make overall plans to promote rural ecological revitalization and rural human settlements improvement. Accelerate the integration, innovation, popularization and application of agricultural input reduction and efficiency enhancement technology, strengthen the resource utilization of agricultural wastes and the classified disposal of waste agricultural films, and focus on areas with prominent agricultural non-point source pollution to strengthen system management. Solidly promote the rural toilet revolution and effectively control rural domestic sewage, garbage and black and odorous water bodies. Establish a rural ecological environment monitoring and evaluation system. Scientifically promote rural greening and beautification, and strengthen the protection and utilization of traditional villages and the guidance of rural features. By 2027, the proportion of completed counties in beautiful countryside will reach 40%; By 2035, beautiful countryside will be basically completed.

　　(twenty) to carry out innovation demonstration. Classified policies to promote the construction of this beautiful city, the implementation of beautiful countryside demonstration county construction action, continue to promote beautiful rivers and lakes, beautiful bay excellent cases. Promote the integration of beautiful China construction into grassroots governance innovation. Further promote the demonstration construction of ecological civilization and promote the construction of "Lucid waters and lush mountains are invaluable assets" practice and innovation base. Encourage green innovation in the Pilot Free Trade Zone. Support practical innovations such as planning policies for the construction of beautiful China.

　　Eight, to carry out the beautiful China to build a national action.

　　(twenty-one) to cultivate and promote ecological culture. Improve the ecological culture system based on ecological values, cultivate the mainstream values of ecological civilization, and accelerate the formation of ecological consciousness of the whole people. Excavate Chinese excellent traditional ecological culture thoughts and resources, and launch a number of excellent ecological literature masterpieces to promote the prosperity and development of ecological culture. Make full use of museums, exhibition halls and science and education halls to publicize the vivid practice of building beautiful China.

　　(twenty-two) to practice a green and low-carbon lifestyle. Advocate a simple and moderate, green and low-carbon, civilized and healthy lifestyle and consumption pattern. Develop green tourism. Continue to promote the "CD Action" and resolutely stop food and beverage waste. Encourage green travel, promote the construction of urban greenway network, and thoroughly implement the priority development strategy of urban public transport. Carry out the patriotic health campaign in depth. Improve the level of waste classification management and promote the full coverage of waste classification in urban residential areas at prefecture level and above. Establish a standard, certification and labeling system for green and low-carbon products, and explore the establishment of public participation mechanisms such as "carbon inclusiveness".

　　(twenty-three) to establish a multi-participation action system. Continue to carry out the "Beautiful China, I am an actor" series of activities. Give full play to the bridge role of trade associations, chambers of commerce and mass organizations’ extensive mobilization role, improve the public ecological environment supervision and reporting feedback mechanism, and promote the construction of ecological environment volunteer service system. Deepen the opening of environmental protection facilities and provide publicity and education services for ecological civilization to the public.

　　Nine, improve the beautiful China construction guarantee system.

　　(twenty-four) reform and improve the system and mechanism. Deepen the reform of the ecological civilization system and promote system integration and mechanism innovation as a whole. Strengthen the protection of the rule of law in the construction of beautiful China, promote the formulation and revision of relevant laws in the fields of ecological environment, resources and energy, promote the compilation of ecological environment codes, improve public interest litigation, strengthen judicial protection in the field of ecological environment, and make overall plans to promote compensation for ecological environment damage. Strengthen the coordination and cooperation between administrative law enforcement and judicature, and strengthen the convergence and cooperation in information notification, situation consultation, evidence collection, dispute resolution and ecological restoration. Build a big pattern of protection and governance from the top of the mountain to the ocean, and implement the strictest ecological environment governance system. Improve the source prevention management system of environmental impact assessment, fully implement the pollutant discharge permit system, and accelerate the construction of environmental credit supervision system. Deepen the reform of the legal disclosure system of environmental information and explore the evaluation of environmental, social and corporate governance. Improve the management system of natural resources assets and improve the control system of land and space use. Strengthen the system of river and lake length and forest length. We will further promote the audit of leading cadres’ natural resources assets. Those who make blind decisions regardless of the ecological environment and cause serious consequences will be strictly accountable and lifelong accountable according to the rules and regulations. Strengthen the national natural resources inspector. Give full play to the functions of the ecological environment department and strengthen the overall coordination, supervision and management of ecology and environment. Deepen the reform of the vertical management system for monitoring, supervision and law enforcement of eco-environmental institutions below the provincial level. Implement the professional training project of ecological environment team in cities and counties. Accelerate the formulation and revision of standards and norms in key areas of the construction of beautiful China, carry out environmental benchmark research, and revise standards such as ambient air quality in a timely manner.Encourage the introduction of local regulations and standards.

　　(twenty-five) to strengthen the incentive policy. We will improve the market-oriented allocation system of resources and environmental factors, and include carbon emission rights, energy use rights, water use rights, and emission rights in the total plate of market-oriented allocation reform of factors. Strengthen tax policy support, strictly implement the environmental protection tax law, improve the collection system, and accelerate the inclusion of volatile organic compounds in the collection scope. Strengthen the application of cleaner production audit and evaluation certification results. Comprehensively consider the energy consumption and environmental performance level of enterprises, and improve the ladder electricity price system of high-energy-consuming industries. Implement the sewage treatment charging policy, and build a charging mechanism that covers the cost of sewage treatment and sludge disposal and is reasonable and profitable. Improve the economic incentive policy oriented to the green development of agriculture, support the reduction and increase of chemical fertilizers and pesticides, and promote the collection, treatment and utilization of livestock manure in the whole county. Establish a system for extracting and using the eco-environmental protection expenses of enterprises. Improve the value realization mechanism of ecological products, and promote the innovation of eco-environment-oriented development model and investment and financing model. Promote comprehensive ecological compensation and deepen the construction of compensation mechanism for horizontal ecological protection. Strengthen financial support for the construction of beautiful China, optimize the allocation of financial resources in the field of ecological civilization construction, and ensure that the investment scale matches the construction task. Vigorously develop green finance, support qualified enterprises to issue green bonds, guide various financial institutions and social capital to increase investment, explore financial support models for regional environmental protection construction projects, steadily promote climate investment and financing innovation, and provide financing support for the construction of beautiful China.

　　(twenty-six) to strengthen scientific and technological support. Promote the self-reliance of green and low-carbon science and technology, innovate the system and mechanism of ecological environment science and technology, and build a market-oriented green technology innovation system. Pollution reduction and carbon reduction, coordinated emission reduction of multiple pollutants, climate change response, biodiversity protection, new pollutant control and nuclear safety are regarded as key areas of national basic research and scientific and technological innovation, and key core technologies are strengthened. Strengthen the deep integration of Industry-University-Research led by enterprises, guide enterprises, universities and scientific research units to build a number of green and low-carbon industrial innovation centers, and increase the supply of efficient green environmental protection technology and equipment products. We will carry out major actions of scientific and technological innovation in ecological environment, promote the major project of "Scientific and Technological Innovation 2030-Beijing-Tianjin-Hebei Comprehensive Environmental Management", and build innovative platforms such as scientific apparatus and key laboratories, engineering technology centers and scientific observation and research stations in the field of ecological environment. Strengthen the construction of think tanks in the field of ecological civilization. Support universities and scientific research units to strengthen the construction of environmental disciplines. Implement high-level eco-environmental science and technology talent project and cultivate a high-level eco-environmental talent team.

　　(27) Accelerate digital empowerment. Deepen the application of digital technologies such as artificial intelligence, build a beautiful digital governance system in China, and build a green and intelligent digital ecological civilization. Implement the ecological environment informatization project and strengthen the integration and sharing of data resources and comprehensive development and utilization. Accelerate the establishment of a modern ecological environment monitoring system, improve the integrated monitoring network of the sky, the earth and the sea, strengthen the supervision and monitoring of ecological quality, and promote the research and development of ecological environment satellite loads. Strengthen the monitoring capacity building of greenhouse gases, groundwater, new pollutants, noise, ocean, radiation, rural environment, etc., and achieve full coverage of coordinated monitoring of carbon reduction, pollution reduction and greening. Improve the level of ecological environment quality prediction. Implement national environmental law-abiding actions, implement classified law enforcement supervision of pollutant discharge units, vigorously implement off-site law enforcement, and accelerate the formation of a smart law enforcement system.

　　(twenty-eight) the implementation of major projects. Accelerate the implementation of pollution reduction and carbon reduction collaborative projects, support low-carbon energy structure, clean mobile sources, green key industries, and circular transformation of industrial parks. Accelerate the implementation of environmental quality improvement projects, support pollution reduction in key areas, comprehensive management of important rivers, lakes and bays, prevention and control of soil pollution sources, prevention and control of environmental risks of hazardous wastes, and treatment of new pollutants. Accelerate the implementation of ecological protection and restoration projects, support biodiversity protection, sand prevention and control in key areas, and comprehensive prevention and control of soil erosion. Accelerate the implementation of modern ecological environment infrastructure construction projects, support urban and rural and park environmental facilities, ecological environment wisdom perception and monitoring law enforcement emergency, nuclear and radiation safety supervision, etc.

　　(twenty-nine) to seek common ground for the construction of global ecological civilization. Adhere to the concept of community of human destiny and build a clean and beautiful world together. Adhere to the principle of common but differentiated responsibilities and promote the construction of a fair, reasonable, win-win global environmental climate governance system. Deepen international cooperation in climate change, biodiversity protection, marine pollution control and nuclear safety. Continue to promote the green development of the "Belt and Road".

　　X. Strengthening the overall leadership of the Party

　　(30) Strengthen organizational leadership. Adhere to and strengthen the Party’s overall leadership over the construction of beautiful China, and improve the working mechanism of overall planning by the central government, overall responsibility by the province and implementation by cities and counties. Give full play to the overall coordination, guidance and supervision role of the central leading group for ecological environmental protection supervision, improve the working mechanism, and strengthen organization and implementation. To study and formulate regulations on the supervision of ecological environmental protection. Further promote the central eco-environmental protection inspectors, focusing on the construction of beautiful China. Continue to shoot and make eco-environmental warning films. Formulate the responsibility system for ecological environment protection of local party and government leading cadres, and establish a comprehensive responsibility system with consistent powers and responsibilities, clear rewards and punishments, and interlocking. All localities and departments should take the construction of beautiful China as a major task that has a bearing on the overall situation, implement the principle of "Party and government sharing responsibilities, one post and two responsibilities", and study and solve major problems in time. People’s congresses at all levels and their standing committees have strengthened the legislative work of ecological civilization construction and the supervision of law enforcement. CPPCC at all levels intensified special consultation and democratic supervision on ecological civilization construction. The annual work of promoting the construction of beautiful China by relevant departments in various regions shall be sent to the Ministry of Ecology and Environment in writing, which shall report to the CPC Central Committee and the State Council after being summarized.

　　(31) Compaction responsibility. The Ministry of Ecology and Environment, together with the National Development and Reform Commission and other relevant departments, will formulate action plans in different fields, establish a work coordination mechanism, accelerate the formation of a beautiful China construction implementation system and promote the implementation mechanism, promote the project, inventory and accountability of tasks, and strengthen overall coordination, dispatch evaluation and supervision and management. Party committees and governments at all levels should strengthen the political responsibility of ecological environmental protection, implement policies in different categories, manage in different regions, and build in a refined way. Party committees and governments of provinces (autonomous regions and municipalities directly under the Central Government) shall formulate supporting documents in a timely manner in light of local conditions. All relevant departments should strengthen the convergence of work, grasp the rhythm and intensity, coordinate and promote each other, and strengthen the fiscal, taxation, finance, price and other policy support for major projects in beautiful China.

　　(32) Strengthen publicity and promotion. We will continue to deepen the theoretical research, study and publicity, system innovation, practice promotion and international dissemination of the supreme leader’s ecological civilization thought, and promote the integration of ecological civilization education into the cadre education, party member education and national education system. Strengthen the propaganda of ecological civilization through various forms such as National Ecological Day and Environment Day. Release the White Paper on Beautiful China Construction. In accordance with the relevant provisions in recognition of outstanding achievements and outstanding contributions in the construction of beautiful China advanced units and individuals.

　　(thirty-three) to carry out effectiveness assessment. Carry out monitoring and evaluation of beautiful China, and evaluate the construction process of beautiful China. Study and establish the evaluation index system of the construction effectiveness of beautiful China, formulate the evaluation method of the construction effectiveness of beautiful China, and timely transfer the evaluation of the effectiveness of the tough battle of pollution prevention to the evaluation of the construction effectiveness of beautiful China. The evaluation work is led by the central leading group for the supervision of ecological environmental protection, and the evaluation results serve as an important reference for the comprehensive evaluation, rewards and punishments, appointment and dismissal of leading bodies at all levels and relevant leading cadres.

The State Council Joint Prevention and Control Mechanism held a press conference at 15: 00 on February 23rd to introduce the situation of consolidating the major achievements in epidemic prevention and control. Pay attention together!

China has smoothly entered the stage of normalized prevention and control of "Class B and B Management"

Recently, the epidemic situation in various places has been sporadic, and the prevention and control situation has generally improved, smoothly entering the stage of "Class B and B management" normalization prevention and control. For more than three years, we have always insisted on optimizing and adjusting prevention and control policies and measures according to the situation, effectively coordinating epidemic prevention and control and economic and social development, successfully avoiding the widespread spread of virus strains with strong pathogenicity and high mortality, and effectively protecting people’s lives and health. Through the concerted efforts of the whole party and the people of all ethnic groups throughout the country to fight the epidemic, China has achieved a major and decisive victory in epidemic prevention and control.

At present, the global epidemic is still prevalent and the virus is constantly mutating. It is necessary to focus on "protecting health and preventing serious diseases", compact the "four-party responsibility", keep an eye on key links, continue to improve the measures of "Class B and B management", and further enhance the ability of normalization prevention and control and emergency response.

It is necessary to strengthen epidemic monitoring and normalized early warning, closely track and study the variation and spread of the virus, and improve the ability of early detection, early disposal and emergency response of the epidemic. Optimize the grading diagnosis and treatment mechanism and improve the ability of medical treatment. We will continue to prevent and control epidemics in nursing homes, social welfare homes, child care institutions and schools, and strengthen health services for key groups such as the elderly and children. Accelerate vaccination in COVID-19, raise people’s awareness of disease prevention, and build a social defense line for epidemic prevention and control.

What is the sign of getting out of the epidemic?

The concept of pandemic is an index reflecting the epidemic intensity of a disease. From the perspective of public health, the epidemic intensity of a disease epidemic can be divided into four categories, one is sporadic, the other is outbreak, and the other is epidemic, that is, the epidemic spread widely, achieving cross-city and inter-provincial spread. The strongest intensity is the pandemic, which has spread across countries and continents. In March 2020, the World Health Organization announced that this epidemic situation was a pandemic. At the same time, the epidemic situation of this disease announced at the end of January 2021 has constituted a public health emergency of international concern, and it is still a public health emergency of international concern. From a global perspective, the state of pandemic still exists, and the harm of the disease still exists. However, our country can say that the whole Covid-19 epidemic prevention and control, we have achieved a major decisive victory, but also as a populous country, successfully out of the pandemic, we have created a model.

Speaking of getting out of the sign of pandemic, we can actually have different indicators from different angles. From the perspective of epidemic prevention and control, especially public health, one indicator is what the infection rate of this disease is, and the other is the cumulative infection rate, that is, the total infection rate in a certain period of time among a region, a country and a population. There is also a new infection rate, such as how many people have new infections every day and how many people have new infections in a specific population. Another index is the immune level or immune rate of the population, which is to judge the level of antibodies in the body, that is, the state of anti-immune barrier and immune protection rate. The third indicator is to see the pathogen, that is, whether there is any qualitative and public health significance variation in Covid-19. The fourth is from the perspective of medical and health providers, the daily number of outpatients, hospitalization, severe cases, deaths, and the ability of the entire medical and health system to cope. Finally, it depends on whether the whole prevention and control ability, from mechanism to means and ability to control the disease are basically available. These aspects are important indicators to determine how to get out of the pandemic.

Speaking of "decisive victory", in fact, for our country, it means that we have withstood the impact and test of this round of epidemic and established a better population immune barrier. From the characteristics of the epidemic itself, it can be said that the epidemic has basically ended, but it cannot be said that it is completely over. In our country, the current infection is still in a sporadic and local sporadic state.

What are the infection symptoms of XBB.1.5? Is it possible to trigger a new round of infection peak?

Since Covid-19 was infected with "Type B B tube" on January 8th this year, 7 cases of local associated XBB.1.5 cases caused by imported cases have been found through monitoring, which are the core close contact personnel. After detailed epidemiological investigation, health examination of relevant close contact personnel and expert judgment, no further cases were found. According to the data of the CDC website in the United States, from February 12 to 18, XBB.1.5 accounted for the first place (about 80.2%) among the epidemic strains in the United States, and it also accounted for a relatively high proportion in several countries in Europe and America, such as Canada (37.8%), Britain (32.9%) and Germany (25.7%). Although XBB.1.5 has strong transmission power, the current data show that the symptoms of individuals infected with XBB.1.5 are similar to those of other Omicron strains, and no increase in pathogenicity has been found.

At present, in the detection of mutant strains in Covid-19, if the first reported (including imported and local) and international epidemic strains are found, the infection case investigation and core close contact investigation will be carried out, and the risk judgment will be carried out. Once a new mutant strain with enhanced transmission, pathogenicity or virulence is found, measures will be taken in time according to relevant plans. At the same time, China has just experienced a pandemic, and the neutralizing antibodies retained in the population will provide immune protection in a short period of time. Experts believe that it is unlikely to trigger a new round of epidemic in the near future.

Recent fever and diarrhea may be acute gastroenteritis.

After Covid-19’s infection, the main symptoms are fever, dry throat, sore throat and cough, and some patients may be accompanied by diarrhea. When there are symptoms of fever and diarrhea, we should focus on whether it is an intestinal disease such as acute gastroenteritis, especially at present, when norovirus infection is high. Recently, the website of CDC and WeChat WeChat official account have successively released health tips on norovirus infection, so the public can take precautions according to the relevant tips.

Preventive measures in COVID-19 are equally effective for respiratory infectious diseases.

At present, it is the epidemic season of respiratory infectious diseases such as influenza and respiratory syncytial virus infection in China, and it is necessary to continue to strengthen the monitoring and early warning of respiratory viruses such as influenza; Nursery institutions, schools, nursing homes and other key institutions are crowded and the environment is relatively closed. They are places with high incidence of infectious diseases such as respiratory tract and need to be paid special attention to. Relevant institutions should do a good job in symptom monitoring, and report to the local disease control institutions in time when there are more cases of fever and other symptoms. According to the published disposal plan of influenza and other related infectious diseases, local disease control institutions make corresponding disposal according to the scale of the epidemic and the actual situation on the spot.

For influenza, annual vaccination is the most economical and effective preventive measure. At present, Covid-19 infection still occurs in some parts of China, so we should continue to do personal protection, adhere to good hygiene habits such as frequent hand washing, scientific wearing of masks, frequent ventilation in rooms, keeping social distance and cough etiquette; Pay attention to maintaining a healthy lifestyle such as regular work and rest, reasonable diet and moderate exercise.

Preventive measures against Covid-19 infection are equally effective for respiratory infectious diseases such as influenza and respiratory syncytial virus infection.

Vaccination status of the elderly population in Covid-19

At present, the coverage of the elderly over 60 years old in China is 241.688 million, 230.306 million people have been vaccinated in the whole process, and 233.11 million people have been vaccinated. Based on the population of the national special survey of the elderly at the end of 2022, the coverage of vaccination accounts for 96.1% of the elderly population, and the whole vaccination and enhanced immunization account for 96.6% and 92.4% of the elderly population that meet the vaccination interval respectively.

How to dynamically grasp the infection level and changing trend of Covid-19 in China?

In December, 2022, in order to dynamically grasp the infection level and changing trend in Covid-19, timely monitor the variation of virus and biological characteristics, and evaluate the load of medical resources, the National Health and Wellness Commission, the National Bureau of Disease Control and Prevention, together with relevant departments, further expanded the monitoring channels and formed multiple monitoring subsystems on the basis of direct reporting of infectious diseases through the network. Including case report monitoring system, medical institution fever clinic (consulting room) monitoring system, sentinel hospital monitoring system, virus variation monitoring system, sewage monitoring system, key institution clustering epidemic monitoring system, crowd nucleic acid and antigen detection system, medical institution in-hospital case monitoring system, community crowd sentinel monitoring system, network survey system, etc. A multi-channel monitoring system has been initially formed, which takes into account normal and emergency situations, entry and local conditions, urban and rural areas, general population and key population.

In the next step, we will work with relevant departments to further improve the monitoring and early warning system, strengthen the capacity building of epidemic monitoring and normalization early warning, improve the quality of monitoring, strengthen the monitoring and early warning mechanism, and improve the team of interdisciplinary and multidisciplinary experts.