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From "Walking Measurement" to "Sky and Land" Integrated Monitoring —— Science and Technology Helps Hainan Tropical Rainforest Protection

  Xinhua News Agency, Haikou, September 11th Title: From "foot measurement" to "sky and land" integrated monitoring — — Science and technology help Hainan tropical rain forest protection

  Xinhua News Agency reporters Chen Kaizi and Yuan Rui

  Kingfisher jumps into the water, with fish in its mouth; The round-nosed monitor lizard travels slowly, looking for delicious food in the forest; Gibbons climb on the treetops and sing loudly … … These scenes of Hainan tropical rain forest are being recorded and presented in real time by remote monitoring system.

  The picture shows the ecological monitoring platform in Bawangling area of Hainan Tropical Rainforest National Park. Xinhua News Agency reporter Fan Yuqing photo

  Since the national park system was piloted in 2019, Hainan has made great efforts to build a new model of intelligent ecological management and protection. Hainan Rainforest National Park Administration has built a provincial-level smart management center and a smart rainforest big data center platform, and carried out "electronic fence" construction pilot projects in Bawangling, Diaoluoshan and Wuzhishan, and started the "sky-land" integrated monitoring system project of Hainan Rainforest National Park, exploring the construction of a four-in-one tropical rainforest monitoring system of "forest dynamic monitoring sample plot+satellite sample plot+random sample plot+kilometer grid sample plot".

  On the monitoring screen of Jianfengling Branch of Hainan Tropical Rainforest National Park Administration, the video can be switched to multi-angle high-definition images at any time, and live broadcast can be realized by connecting with the camera installed in the rainforest.

  The forest coverage rate of Jianfengling area is over 97%, which is rich in biological resources and is one of the hot spots of biodiversity in the world. "Through ‘ Electronic fence ’ And multi-functional monitoring system, we have greatly reduced the number of people entering the mountains and found many species that have not been seen for a long time. " Yang Shibin, deputy director of Jianfengling Branch of Hainan Tropical Rainforest National Park Administration, said.

  In addition to ecological protection and resource monitoring, scientific and technological means are also applied to the daily patrol and maintenance of Hainan tropical rain forest.

  The Wuzhishan area of Hainan Tropical Rainforest National Park has pleasant scenery. Xinhua News Agency reporter Zhang Lizhen photo

  In Bawangling area, the information-based patrol management platform is connected with the special mobile phone equipped by rangers, which can check their patrol time and route in real time, and realize standardized and information-based management of patrol work. The application of science and technology, such as fire remote video monitoring watchtower and fire video monitoring command center, has improved the ability of forest protection and fire prevention.

  "From the older generation of scientists ‘ Measurement on foot ’ , until now ‘ Sky land ’ Integrated and comprehensive monitoring, Hainan Tropical Rainforest National Park has initially established a long-term positioning monitoring system for natural resources and biodiversity, and through it, it has carried out the protection and management of tropical rainforest ecosystems, key species habitats and ecological environment, as well as biodiversity and forest carbon sinks. Scientific research. " Wang Nan, deputy director of Hainan Rainforest National Park Administration, said, "In addition, a series of other scientific and technological means are also helping the effective management and protection of Hainan Rainforest."

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Fever and cough are not the first symptoms! The People’s Hospital of Wuhan University released the "upgraded version" of new pneumonia patient identification.

  CCTV News:After being infected with new coronavirus pneumonia, will it definitely show fever and respiratory symptoms?

  On January 24th, the research group of Wuhan University People’s Hospital released "Attach great importance to the first symptoms of non-respiratory system — — Identification and protection of patients with new coronavirus pneumonia (2019-nCOV) reminds medical staff and the public to be highly alert to the invisible source of infection with non-respiratory symptoms as the first symptom.

  The Notice on Printing and Distributing the Diagnosis and Treatment Plan for Pneumonia Infected in novel coronavirus (Trial Third Edition) issued by the authoritative department points out that the main clinical manifestations of new coronavirus pneumonia are fever, fatigue and dry cough. At present, many "atypical" cases have been found in the process of diagnosis and treatment of new pneumonia in the Department of Gastroenterology, Respiratory and Critical Care Medicine of Wuhan University People’s Hospital.

  Professor Yu Honggang, director of the Department of Gastroenterology, People’s Hospital of Wuhan University, introduced an atypical case. A 45-year-old man went to the gastroenterology clinic for three days because of diarrhea. The doctor repeatedly asked about his medical history and confirmed that he had a history of contact with new coronavirus pneumonia, but he had no obvious fever and related respiratory symptoms. The attending doctor considers that he is in the epidemic development period and has a clear contact history, and performs chest CT after fully communicating with the patient. The results suggested that there were multiple flaky ground-glass images in both lungs, and the novel coronavirus nucleic acid test in throat swab showed positive, which was finally diagnosed as a new type of coronavirus pneumonia.

  Professor Chen Guozhong, director of Department I of Respiratory and Critical Care, People’s Hospital of Wuhan University, said that in the above-mentioned clinical cases, patients did not have typical respiratory symptoms such as fever and cough when they saw a doctor, but only recently appeared non-respiratory symptoms after contact with suspected or confirmed novel coronavirus patients. Digestive system: such as mild anorexia (anorexia), fatigue, poor spirit, nausea and vomiting, diarrhea, etc. Nervous system: such as headache; Cardiovascular system: such as palpitation, chest tightness, etc. Ophthalmology: such as conjunctivitis; Other aspects, such as only mild limb or back muscle pain.

  The results highly warn medical staff and the public that we should further strengthen the understanding of the symptoms of new coronavirus pneumonia, and at the same time strengthen the identification and protection. Experts remind that the above-mentioned patients with non-respiratory system as the first manifestation are easy to go to relevant departments (such as gastroenterology, neurology, cardiovascular medicine, etc.), especially in gastroenterology. Because these patients lack obvious specific clinical manifestations, it obviously increases the difficulty of diagnosis, easily leads to missed diagnosis or misdiagnosis, and increases the chance of infection.

  The results also warn that patients are easy to ignore themselves because they have no fever and respiratory symptoms. Because the patients in the incubation period are also contagious, the infectivity will be enhanced before and after the onset of the disease, so this kind of "atypical" patients will also be a very important hidden source of infection, and self-isolation needs to be strengthened.

  The research team specially reminded that medical staff should ask the patient’s medical history in more detail, especially for the contact history of patients with suspected diagnosis or confirmed diagnosis, and whether there was a history of fever in the past two weeks. At the same time, for this kind of "atypical" cases, blood routine and respiratory tract pathogen detection should be carried out in time, and chest CT examination should be carried out if conditions permit. At the same time, we should fully communicate with patients and their families. If it is abnormal, the detection of coronavirus should be further improved. The research team particularly emphasized that it is not recommended to have chest X-ray examination of patients during the epidemic period, because chest X-ray can not find early exudative lesions, which may easily lead to missed diagnosis.

  For the public, it is more important to realize that "early prevention, early detection, early diagnosis, early isolation and early treatment" is the key to prevent and treat the new type of coronavirus pneumonia. We should further raise our awareness of protection every day, wear masks when going out, avoid going to crowded public places, and especially emphasize reducing family gatherings; Wash your hands and face frequently, and pay attention to regular disinfection of mobile phones and public computer keyboards; Learn the correct way to cough and sneeze, and no spitting; Don’t throw away the used masks at will, put them in garbage bags and seal them. (Ren Yixuan)

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All the community isolation treatment facilities in Hong Kong aided by the central government were delivered, providing a solid guarantee for the fight against the epidemic.

The Paper (www.thepaper.cn) learned from China Construction International Group Co., Ltd. (hereinafter referred to as "China Construction International Group") that on June 21st, two community isolation treatment facilities (hereinafter referred to as "projects") aided by the central government in Penny’s Bay and Kai Tak were completed.

Huang Weilun, Director of the Development Bureau of the Hong Kong SAR Government, said at the delivery ceremony of the above-mentioned projects that the central government is the strongest backing of Hong Kong. He once again thanked the Central Committee for its guidance and full support, the Liaison Office of Hong Kong for its guidance and coordination, the full cooperation of various departments of the SAR Government, and the construction team for working against the clock, so that the project could be delivered in batches on schedule, greatly enhancing Hong Kong’s ability to fight the epidemic.

The above two projects have been delivered in batches since construction started in February this year. Up to now, a total of about 10,000 rooms have been provided, all of which were designed and built by China Construction International Group.

After the outbreak of The 5th Wave in Hong Kong, the central government decided to build 10 epidemic prevention facilities in Hong Kong. China Construction International Group was responsible for building 8 of them, including 6 temporary community isolation facilities and 2 permanent community isolation treatment facilities. The 6 temporary community isolation facilities were delivered on March 24th.

The completion and delivery of Penny’s Bay and Kai Tak projects also marks the delivery of all the epidemic prevention projects aided by the central government to Hong Kong.

"At present, the epidemic situation in Hong Kong has eased, but it still cannot be relaxed. We will concentrate all our efforts to promote the rapid completion of the project and provide a solid guarantee for Hong Kong to fight the COVID-19 epidemic in The 5th Wave. " Ye Hong, deputy commander-in-chief of the Central Committee’s aid to the Penny’s Bay Community Isolation Treatment Facility Project in Hong Kong, said.

The community isolation treatment facility in Kai Tak, which was assisted by the Central Government, was completed and delivered on June 21st. All the pictures in this article are provided by China Construction International Group.

"More than 90% of the workload has been prefabricated in the factory"

The two projects, Penny’s Bay and Kai Tak, which were aided by the central government, received the construction task on February 18th, and were formally constructed on February 19th, and delivered on June 21st.

The Kai Tak project is located next to the cruise terminal of the runway of the old airport in Kai Tak, Hong Kong. It covers an area of nearly 110,000 square meters and has a building area of over 110,000 square meters. It includes four-storey MiC quarantine facilities and other ancillary facilities, providing more than 2,700 isolation units and more than 6,000 isolation beds (including standard rooms, disabled suites, family suites and other rooms). It is the first four-storey community treatment facility in Hong Kong with elevator system. Upon completion, it will become the highest level permanent community isolation treatment facility project in Hong Kong.

Penny’s Bay Project is located in the northeast of Lantau Island, New Territories, Hong Kong. It covers an area of about 450,000 square meters, with a building area of about 272,000 square meters. It is divided into six areas, each of which is equipped with auxiliary facilities such as medical treatment, office and storage. It is the largest community isolation treatment facility project in Hong Kong.

During the design and construction of the above-mentioned projects, China State Construction International Group took epidemic prevention emergency and peacetime use into account, fully applied the modular design concept based on DfMA (Design for Manufacturing and Assembly), and at the same time applied MiC (Assembly and Synthesis Building Method) and prefabricated components, and integrated smart construction technology.

"More than 90% of the workload has been prefabricated in the factory." A manager of China State Construction International Group told The Paper that because of the parallel operation of the site and the factory, the site load was reduced, and the construction efficiency, quality and safety were guaranteed. Compared with traditional buildings, the construction period could be reduced by 40% to 90%, the material loss in the construction process could be reduced by more than 25%, the construction carbon emission by more than 50% and the construction waste emission by more than 70%.

The community isolation treatment facility in Penny’s Bay, a central aid port, was completed and delivered on June 21st.

Penny’s Bay and Kai Tak projects are in accordance with Hong Kong’s permanent building standards and Hong Kong’s building regulations, which can meet the durability requirements for 50 years. The whole cycle is safe and reliable. A single MiC box weighs 12 tons and can withstand a typhoon of magnitude 17.

Not only that, but also in the design and construction, it is more humanized. It not only has good shock-proof, sound insulation and heat insulation effects, but also requires extremely high details such as cleaning partition, drainage, sewage discharge and exhaust, and strictly implements the infection control standards of Hong Kong Quarantine Center.

Faced with the force majeure such as epidemic situation and weather, the construction team faced several challenges, such as short time, difficult recruitment, large workload, poor logistics and insufficient raw materials, but in the end the construction team broke through multiple challenges.

"We have built a life-cycle management system for intelligent traffic scheduling, from the factory production and maritime transportation of MiC boxes to warehousing and installation, to achieve life-cycle management." Liu Baoqing, the commander of the central government’s aid to build Hong Kong Kai Tak community isolation treatment facilities, said.

According to the materials provided by China Construction International Group, as the "rear area" of this project, Zhongjian Hailong Technology Co., Ltd. (hereinafter referred to as "Zhongjian Hailong") under the group undertakes the heavy responsibility of producing and transporting 10,032 main modules and 7,630 functional modules of two centrally aided community isolation treatment facilities projects, and its task scale is equivalent to 11 Vulcan Mountains.

In order to deliver all boxes with good quality and quantity, the company mobilized all available forces, worked 24 hours a day, completed drawing design in 2 days, purchased 50,000 tons of steel and hundreds of materials in 7 days, convened more than 400 managers and 5,300 workers in 10 days, and sent the first batch of MiC to Hong Kong in 14 days.

Shandong Hailong and Chongqing Hailong bases under China Construction Hailong stopped about 90% of their own production capacity, put all available production lines and personnel into the project, and completed materials procurement, box production, box decoration and other work in a very short time through professional integration and cross-deepening design and factory processing and prefabrication, with an average of more than 13,000 people starting work in a single day during the peak period.

Make every "impossible task" possible.

For all builders, this central aid to Hong Kong is an unforgettable life experience.

"Looking back at the beginning of the project, we are faced with the situation that we have to start work everywhere, design everywhere, and coordinate everywhere. Many employees have taken the initiative to come from all over the country to support, and they feel very embarrassed when they can’t come." Liu Baoqing said that he was deeply impressed by a project manager of the team who was unfortunately diagnosed with COVID-19 due to family contact. The project manager apologized for not being able to make efforts for the project.

"I was also very moved at that moment." Liu Baoqing said that the service life of the Kai Tak project he is responsible for is 50 years. Compared with several shelter projects completed in advance, this project needs to work together to achieve the goal.

Workers are working on the site of the community isolation treatment facility in Kai Tak, which is aided by the Central Government.

"We have been surpassing ourselves and breaking through the limits." Liu Baoqing said.

As an internal engineer of Kai Tak Project, Tong Anqi and the team are responsible for the ground structure and related projects at the project site.

He remembers that when the project started, Hong Kong was particularly wet and cold, and the somatosensory temperature was very low, and all the colleagues’ shoes were soaked. At that time, he thought, "This project must be a hard battle in the future."

Since then, it has proved to be true.

"At the beginning, due to the shortage of manpower, many colleagues were unable to go to work due to isolation, but there were still many colleagues who took the initiative to contact me and volunteered to participate in the war. Some of them have several jobs, and some colleagues and children have just been born, but they still come to the Kai Tak project without hesitation. At that time, they raised their hands, which still made me unforgettable. " Yan Anzhen said.

Jia Tao is also an internal engineer in the Kai Tak Community Project. He has previously participated in the construction of the emergency epidemic prevention and isolation center in Lei Yue Mun, Hong Kong and the temporary hospital in Hong Kong aided by the central government. Compared with before, this is the first time he is in charge of an engineering section, so he feels "great responsibility".

"For our planning and arrangement ability, communication and coordination ability, it is an’ upgraded version’ test." Jia Tao said that the Penny’s Bay project also faces several major challenges, such as large construction area, large number of people starting work and congenital insufficient traffic conditions.

Therefore, the construction team set up a matrix management system, publicized the construction plan to each team in time, held daily communication meetings on safety and environmental protection progress, promptly resumed trading, and investigated hidden dangers. It took 10 days to actively negotiate with the government to build two new docks to ensure that MiC boxes transported from the mainland were unloaded through the docks.

"From the earliest participation in the Lei Yue Mun project to the present, every time I feel that it is an impossible task, but with the joint efforts of our brothers, all these impossibilities have become possible." Ye Hong concluded.

He served as the deputy commander of Penny’s Bay Project this time, and had rich experience in epidemic prevention project construction before. In 2020, he participated in the emergency quarantine center project of Hong Kong Lei Yue Men Park Resort and the construction of phases 1B and 3B of Penny’s Bay Quarantine Center project, and was stationed in the factory of Zhongjian Hailong in Zhuhai to be responsible for the production and transportation of MiC boxes.

"This Penny’s Bay project involves more than 7,000 boxes, which is nearly 10 times the size of a single project at that time, but we have achieved great compression in time." Ye Hong said that during this construction, he fully felt the rapid development of the company’s rapid construction technology.

"This time, when I really have the opportunity to take charge of a specific work of the project, I will want to make my own contribution to the motherland and Hong Kong like my predecessors." Zheng Juehui, an engineer in the Penny’s Bay project aided by the central government, said that at the end of 2020, he had just arrived in Hong Kong to take part in the construction of the temporary hospital project aided by the central government in Hong Kong. This time, he was mainly responsible for material procurement, receipt, distribution and warehouse management in the Penny’s Bay project.

As a Hong Kong resident who participated in the epidemic prevention project for the first time, Zhang Weiquan claimed that he felt "a sense of honor" when he could participate in the epidemic prevention project.

Chen Bihua, who is also a Hong Kong resident, served as the subcontractor evaluation of the Kai Tak community isolation treatment facility project, and was responsible for the deployment of front-line construction workers, machinery and equipment of underground facilities such as earthwork, drainage and electric wires.

He has rich experience in the construction of epidemic prevention projects. He has previously participated in the construction of the quarantine center of Lei Yue Men Park Resort, the community treatment facility of Yabo Pavilion and the Hong Kong Infection Control Center of North Lantau Hospital.

At the beginning of the project, Chen Bihua realized the importance of the project to Hong Kong’s social epidemic prevention work, took the initiative to apply for follow-up projects, and devoted himself to the construction of the Kai Tak project.

"It is a meaningful thing to participate in the Kai Tak project. We all hope to contribute to the society and help all Hong Kong citizens." Chen Bihua said.

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A bigger price surprise? Zero-run B05 spy photos with lidar European style are expected to be pre-sold in November.

[car home Information] Recently, Lei Jun announced at the Xiaomi Investor Conference that by April 20th, the number of (|) orders had exceeded 70,000. Among them, the most expensive Max version has the most orders, reaching 43.16%; Followed by the cheapest standard version and the mid-priced Pro version, accounting for 28.57% and 28.27% respectively. In the order, the owners who choose elegant gray are the most, followed by Xiaguang Purple, followed by Bay Blue and Olive Green. Among Xiaomi SU7 users, female buyers account for 28%. Cities that will open NOA in May include Beijing, Shanghai, Guangzhou, Shenzhen, Xi ‘an, Nanjing, Wuhan, Suzhou, Hangzhou and Chengdu. Lei Jun said that the delivery target of Xiaomi SU7 will exceed 100,000 units in 2024.

Home of the car

Home of the car

Home of the car

Home of the car

According to the delivery data in the second week of April, Xiaomi SU7 continued its rapid momentum, and the weekly terminal sales jumped from 1093 to 2397. In contrast, several core competing products are relatively stable, with ups and downs. If this momentum continues, the market structure of 200,000-300,000 yuan may be subverted and changed.

Terminal sales of Xiaomi SU7 and its main competing products in April car make and model The first week of April
Terminal sales
The second week of April
Terminal sales
Terminal sales in April (total) Xiaomi SU7 1093 2397 3490 Tesla Model 3 519 1556 2075 Extreme krypton 001 2625 2303 4928 Extreme krypton 007 450 242 692

Judging from the terminal sales in the second week, not all of them have increased after Qingming. At present, SU7′ s main rival is actually Krypton 001. Although it surpassed Krypton 001 this week, Krypton 001 is relatively stable from the two-week progress. After all, it has certain word-of-mouth support. I believe that the two cars will bite very tightly behind.

Xiaomi Auto Xiaomi SU7 2024 800km four-wheel drive with long battery life and high-order intelligent driving Max version.

Xiaomi Auto Xiaomi SU7 2024 800km four-wheel drive with long battery life and high-order intelligent driving Max version.

In the live broadcast a few days ago, Lei Jun said that after the founding version, the standard version and Max version of Xiaomi SU7 ordinary version (Lei Jun called the official version) have been delivered. According to the plan, the last version of Xiaomi SU7 Pro will be delivered at the end of May. Lei Jun said that the order of Xiaomi SU7 is 3-5 times higher than previously expected, and it is already in full production to meet the delivery.

Xiaomi Auto Xiaomi SU7 2024 800km four-wheel drive with long battery life and high-order intelligent driving Max version.

Xiaomi SU7 is aimed at medium and large cars, with a price of 21.59-29.99 million yuan. The new car is equipped with 8295 chips, which realizes five-screen interconnection including HUD and rear screen, and is equipped with 澎湃 OS system, and can be ecologically interconnected with Xiaomi. The new car is built on the basis of 800V architecture, which can recharge 510km in 15 minutes, with an acceleration time of 2.78 seconds from 0 to 100 km/h, a top speed of 210km/h and a cruising range of 810km for CLTC. Equipped with a laser radar, two NVIDIA DRIVE Orin chips, with a computing power of 508TOPS, the whole system supports high-speed NOA, and the city NOA was subsequently opened. (Source: Lu Weibing; Compile/car home Qin Chao)

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A week is thin! South Korea’s purchasing diet pills became popular and actually contained drug ingredients.

  CCTV News:For weight loss, many people will choose to take diet pills to lose weight. At present, the market is full of all kinds of weight loss products, including some diet pills, which are under the banner of no diet and no exercise. As long as they are eaten, they can effectively drain oil and lose weight. Xiao Yuan of Dalian, Liaoning Province bought some hot-selling diet pills online. Unexpectedly, this diet pill actually contains drugs.

  Xiao Yuan, the victim, said that such a thing as Korean slimming pills is also very popular in the circle of friends. Little girls in Korea are using it, and they have lost about 10 pounds just after eating for a week or so.

  Xiao Yuan, who lives in Dalian, Liaoning Province, found a hot-selling diet pill online in order to recover her figure after giving birth. According to the merchant, this diet pill is very popular in South Korea, and it does not contain any harmful drug ingredients, so the slimming effect is very obvious.

  In the process of taking medicine, Yolanda found some abnormal reactions in her body: when taking medicine, her spirit will become more excited; When you don’t eat, you will feel anxious and flustered.

  However, in a chat with a friend later, Xiao Yuan was reminded by her friend that her reactions were a bit like the state after taking drugs. Xiao Yuan, who was flustered, immediately went to the local public security organ for a urine test.

  Subsequently, the local police immediately tested the ingredients of this slimming drug and found that four of them contained the main ingredients of state-controlled psychotropic drugs to varying degrees.

  After investigation, the main ingredient detected in the diet pills purchased by Xiao Yuan was a psychotropic substance that was forbidden to be manufactured, transported and sold privately by the state. Subsequently, the police launched an investigation into the online shop on suspicion of drug trafficking.

  After investigation, this diet pill was delivered by an online shopping shop called Xiangxiang Korea Daigou, which was registered in Bozhou City, Anhui Province. The online shop was run by two young people. The diet pill sold in the shop was divided into three packages: basic version, enhanced version and extra strong version, and the dosage of each package was different.

  Since July 2017, in one year, the store has received more than 600 orders, with customers in 20 provinces, 4 municipalities and 3 autonomous regions, and accumulated sales of more than 1.3 million yuan.

  After further investigation, the police then locked the suspect Tang, who supplied the online store. Tang had been engaged in prescription drug reselling in Korea for a long time.

  After arriving at the case, Tang confessed that she was a staff member of a plastic surgery institution in South Korea. She prescribed this weight-loss drug with the convenience of her work. In South Korea, this weight-loss drug is actually a prescription drug. The dosage of the drug is determined according to different conditions of everyone. If it is taken in large doses in violation of regulations, it will still do great harm to the human body.

  At present, online shop owners Zhang, Gao and Tang have been criminally detained by Dalian police for allegedly violating the crime of drug trafficking stipulated in Article 347 of China’s Criminal Law and selling toxic harmful food in Article 144, and the case is still under further investigation.

 

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The failure indicator of the "emergency exit" indicator light in Beijing multi-subway station is damaged.

The green "safety exit" indicator light in public places is an important sign to deal with unexpected accidents. Recently, some citizens reported to the Beijing News that some of the "safety exit" indicator lights in the east underground passage of Xidan intersection and Xidan subway station in Xicheng District were out of order and there were potential safety hazards.

The Beijing News reporter visited Xidan, Tianqiao, Puhuangyu, Shilihe, Dawang Road and other subway stations, and found that the "safety exit" indicator light was not lit and the indicator signs were damaged in many stations.

The "safety exit" indicator near Exit D of Xidan subway station has been repaired. Photography/Beijing News reporter Wujiang

The failure of some indicator lights in the underground passage of Xidan intersection was reflected and repaired on the same day.

On the morning of August 16, the reporter visited the east underground passage of Xidan intersection mentioned by the public. There are 18 "safety exit" indicators on the walls on both sides of the passage at intervals of about 8 meters. The fault indicators reflected by the citizens were all repaired at this time. According to the staff, all the indicator lights in the channel have just been overhauled recently, and there is a special person to overhaul the channel equipment once a month. However, in the underground passage on the west side of Xidan intersection, although there are security guards standing guard, there is no "safety exit" indicator or logo.

The east and west passages of Xidan intersection lead to the two entrances and exits of the subway station respectively. The reporter entered Xidan Station of Metro Line 1 along the passage and checked the indicator light along five lines. At Xidan Station, there are indicator lights or signs beside the elevators at each entrance and exit, on the walls of underground passages, and on the columns near the trains. However, at least four indicators are not lit, and many indicators are low in brightness or only partially lit.

The reporter reported the situation to the person in charge of the subway station as a citizen, and the other party recorded it and promised to contact the maintenance personnel to check it on the same day.

In view of the low brightness of some indicator lights, the person in charge said that Metro Line 1 is the first subway in China. Due to the early construction time, some equipment along the station is not as advanced as the newly built subway station. "The low brightness of some indicator lights is not a fault, because they are not used for lighting. When there is an accident and power failure, the surrounding light becomes dim, and then the indicator lights can be seen clearly." The person in charge said that the "safety exit" sign posted on the wall has a fluorescent function, which absorbs light at ordinary times and can also emit light in the dark.

At two o’clock in the afternoon, the reporter came to Xidan subway station again and found that the workers with the words "Beijing Metro Electromechanical" printed on their clothes were leaving with ladders on their backs. The reporter noticed that the indicator light that failed in the morning has been repaired.

At Shilihe subway station on Line 14, a "safety exit" sign has been damaged. Photography/Beijing News reporter Huang Zhecheng

Shilihe and other subway stations are patrolled every day, but the indicator light is still faulty.

On August 17th, the reporter visited Dawanglu Station on Line 1, Puhuangyu Station and Shilihe Station on Line 14, and Tianqiao Station on Line 8. Compared with Line 1, Line 14 and Line 8 are newly opened subway lines in recent years, and the indicator lights in the stations along the lines are brighter and more densely distributed. However, these sites also have indicator failures and broken signs.

At noon that day, the reporter called Beijing Jinggang Metro Co., Ltd., which belongs to Line 14 subway, and the service hotline of Beijing Metro Operation Co., Ltd., which belongs to Line 1, as a citizen to feedback the fault. In the afternoon, the staff of Puhuangyu Station and Shilihe Station on Line 14 called back and said that the lights and signs in the stations had been thoroughly inspected and would be replaced in the near future.

According to the staff of Puhuangyu Station, after receiving the report, three indicator lights were found to be faulty and two indicator signs were damaged. The maintenance personnel will complete the maintenance in the afternoon. The person in charge of Shilihe River detected that two indicator lights were faulty and four indicator signs were damaged. The indicator signs will be replaced in the afternoon and the indicator lights will be replaced in the near future.

The person in charge of all the sites visited by the reporter said that there are special personnel in the station to overhaul all the equipment every month, and there are also people on duty to patrol in turn every day. Why was the indicator light problem not discovered in time? A person in charge said that sometimes there is a large passenger flow during peak hours, and the patrol personnel temporarily handle other emergencies, which may lead to the interruption of the patrol. Next, the patrol will be strengthened.

Mr. Wu, a citizen, believes that when an accident occurs, the public can evacuate in time according to the route indicated by the "safety exit" indicator light. If the indicator light cannot be repaired in time, it may lead to an accident. "It is not difficult to repair it in time, and it doesn’t cost much. The key is whether anyone notices it." Mr. Wu said that especially in some prosperous business districts, the daily passenger flow is large, and more attention should be paid to the safety of related facilities.

At noon on August 19, the reporter came to Shilihe Station and Puhuangyu Station on Line 14 again. The failed indicator light has been repaired and the broken indicator has been replaced.

At Xidan Station of Line 1, the brightness of some "exit" indicators is low.Photography/Beijing News reporter Huang Zhecheng

Tips

If you find the indicator light and other problems, you can contact the subway station staff or call the hotline.

In several subway stations, the reporter did not find the public information of the subway service hotline. Some passengers said that if a problem is found, I don’t know what department to call and what to call to reflect the situation.

In this regard, most subway staff said that they could contact the staff in the station directly, but some people on duty did not know what hotline to call.

The reporter learned that the Beijing subway line belongs to the jurisdiction of different operating companies. Among them, there are 16 operating lines under the jurisdiction of Beijing Metro Operation Co., Ltd., including Line 1, Line 2, Line 5, Line 6, Line 7, Line 8, Line 9, Line 10, Line 13, Line 15, Batong Line, Airport Line, Fangshan Line, changping line, Yizhuang Line and S1 Line. The company’s service hotline is 010-96165.

Beijing Jinggang Metro Co., Ltd. is responsible for the subway operation of Line 4, Line 16, Line 14 and Line Daxing, and its service hotline is 86-010-63988622.

Yanfang Line is managed by Beijing Rail Transit Operation Management Co., Ltd., and the passenger service hotline is 010-87837266.

Beijing News reporter Huang Zhecheng Co-reporter Wujiang

Editor ZhangChang proofreads He Yan.

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The design work of the fruit disassembly of Wuling Bin for the safety of the car

  [car home Technology] I don’t know if everyone in front of the screen knows anything about the 100,000-class pure electric compact car. As far as the author is concerned, the competition of this class of cars is actually quite fierce. On the one hand, it is a price war, on the other hand, it is repeatedly involved in design, safety and configuration. In this class of cars, (|) successfully circled the powder with its retro and beautiful shape. Of course, we don’t talk about design today, but look at the scientific and technological strength behind this boutique car through actual disassembly.

Home of the car

● Five-ring body frame

  The length, width and height of Wuling Binguo are 3950*1708*1580mm respectively, and the wheelbase is 2560mm. Thanks to its front-drive pure electric platform technology, the cabin space utilization can be maximized.

Home of the car

Home of the car

  For small cars, consumers are not only concerned about the performance of their cabin space, but also extremely concerned about their safety. Binguo adopts a five-ring car body frame structure, which can increase the rigidity of the car body and improve NVH performance, and at the same time, it can quickly transfer collision energy when a collision occurs, reduce the intrusion of the passenger compartment and protect the safety of the passengers.

Home of the car

Home of the car

  The A-pillar, B-pillar and sill beam constitute the thermoformed steel door ring, which can bear higher pressure and improve the torsional stiffness and safety of the car body. At the same time, the steel door ring of hot car can also improve the sealing performance and torsional stiffness of the car body, improve NVH performance and enhance ride comfort.

Home of the car

Home of the car

  The energy-absorbing box can reduce the maintenance cost of low-speed (20-30km/h) impact, because the energy-absorbing function of the energy-absorbing box can avoid the damage of the longitudinal beam, and the damaged energy-absorbing box can be replaced separately.

Home of the car

Home of the car

Home of the car

Home of the car

  According to official data, compared with the design of only the front finger beam and the front longitudinal beam, the triple frontal collision-resistant energy-absorbing structure design of Binguo can achieve a 15% improvement in energy absorption efficiency.

Home of the car

  There is also a steel anti-collision beam at the rear of Binguo, but there is no energy-absorbing box between it and the body. Even so, the existence of the anti-collision beam can disperse the impact energy of the rear collision, thus reducing the damage degree of the rear collision accident to the vehicle.

● Robust chassis

  Binguo adopts the suspension combination of front McPherson and rear torsion beam, which is common at the same level. Simple structure, durable leather and low manufacturing cost are a major feature of this suspension form.

Home of the car

  Compared with the open beam, the closed torsion beam with variable cross-section improves the stiffness of the torsion beam by 41% and the bearing capacity accordingly, thus reducing the vibration and improving the ride comfort.

Home of the car

  According to the manufacturer’s introduction, Bingo’s chassis adjustment style is tough, that is, to ensure ride comfort on the basis of achieving good support of the car body. Therefore, bingo will be more stable when driving at high speed, giving people more sense of security, and emergency lane-changing vehicles can also provide good support. Binguo 410km Linxi Exclusive Edition uses a brand-new motor with better performance, and its top speed can reach 130km/h, which is higher than that of other models with 100km/h and 120km/h, so it is quite necessary to match a robust chassis.

Home of the car

  Compared with the 175 and 165 tire widths commonly used in the same class, the wider tread of Bingo standard tires is beneficial to improve tire grip, make the vehicle run more stably, and ensure sufficient braking performance.

Home of the car

Home of the car

  In addition to making great efforts to filter the vibration of the chassis to improve NVH performance, Bingo also made a fuss about the details such as the sealing and sound insulation measures of the passenger compartment. Both the front and rear side doors of Binguo have two complete sealing strips to ensure the tightness of the passenger compartment and avoid the introduction of environmental noise and wind noise into the car. At the same time, the sound-absorbing cotton of the front and rear outer wheel covers of Bingo is made of non-woven fabric +PP+PET+ non-woven fabric, which can effectively absorb the tire noise and the noise generated when the suspension system works.

● Water-cooled flat wire motor and refined battery

  Binguo 410km Lingxi exclusive edition adopts water-cooled flat-wire permanent magnet synchronous motor, which is a three-in-one design and integrates motor, electronic control and differential.

Home of the car

  Compared with the round wire motor, the slot fullness of the flat wire motor is increased by 20%, the contact area between the flat wires is larger, the heat conduction is better, and the heat dissipation capacity is stronger. The power density of the flat wire motor is increased by 0.8kW/kg, and the high efficiency range is expanded by 11%, thus making the maximum efficiency of the motor more than 96%.

Home of the car

  We can see that there is a cooling water jacket on the stator shell of the motor, and the cooling liquid will circulate in the water jacket, taking away the heat generated when the motor works, and improving the continuous high power output performance and durability of the motor.

Home of the car

  Wuling’s refined battery should be familiar to all of you. I introduced this battery in detail in the technical article of Wuling Starlight (click to view).

Home of the car

  The battery core of Shenlian battery can not catch fire or explode in the acupuncture test; In the shallow needling test (the steel needle penetrates 1/3 of the battery thickness), the battery can still discharge normally; When the battery cell is extruded and deformed by external force up to 40%, it can not catch fire or explode. The safety performance at the cell level is quite eye-catching, which is also the key factor for the high safety of Bingo battery system.

Home of the car

  At the level of battery pack, Shenlian battery adopts a structure called MUST, that is, Multifunctional Unitized Structure Technology, a multifunctional integrated battery pack structure technology. The biggest feature of this structure is that the cells are put into the reinforced frame and then installed into the battery pack. This reinforced frame can improve the structural strength of the battery pack by 60%.

Home of the car

  Battery packs have suffered a lot in the laboratory, and it is common to go to the mountains and go to sea. The whole package of Shenlian battery has been tested by temperature change test, water immersion test, high temperature acupuncture test, vibration test, bottom dynamic impact test and charge-discharge test.

More exciting videos are all on the car home video platform.
"Needle Punching Test of Shenlian Battery Core"

  Like mainstream electric vehicles on the market, Bingo’s BMS battery management system also supports Che Yun Intelligent Collaboration. In addition to real-time monitoring of battery status at the vehicle end, all-weather and life-cycle second-level safety inspection will also be carried out in the cloud. When the system detects battery collision, stabbing or overheating, it will actively remind the driver to prevent problems before they happen.

Home of the car

Home of the car

  According to the manufacturer, this can reduce the maintenance cost by 90%. At the same time, Wuling has also strengthened the training of battery maintenance in the 4S after-sales service system. I believe that in time, its after-sales service outlets will be fully equipped with power battery maintenance capabilities. Compared with the power battery specialized service that can be seen in the market now, it is obvious that the official after-sales service can reassure consumers.

Home of the car

  In this regard, I also asked the engineer at the dismantling site whether there will be batteries in the form of direct cooling or water cooling with refrigerant installed on Bingo. The engineer’s reply is vague and only means "on the road". Perhaps in the future, Bingo with more powerful electric drive system will use direct cooling or liquid cooling battery system with active temperature control function, which is worth looking forward to.

● Full text summary:

  Wuling Binguo, as a pure electric small car, has done its homework in terms of cabin space utilization and safety, completely dispelling consumers’ concerns about small space and insecurity of small cars. At the same time, the affordable price of 59,800-88,800 yuan, combined with its fashionable and beautiful shape, is a good choice for buying food scooters in the near future. (Photo/Text/Photo/car home Chang Qinglin)

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Shanghai: The test sites for postgraduate entrance examination will be rearranged according to the nucleic acid results of candidates on the morning of December 21st.

CCTV News:"Published by imperial academy, Shanghai" WeChat official account published a letter to the candidates who took the 2023 research exam in Shanghai.

  Candidates:

  In 2023, the examination for postgraduate entrance examination has entered the countdown. Can go today, at this moment, please applaud yourself first, and applaud yourself for never giving up!

  The examination organization under the normalization of epidemic prevention and control has been going through three years, and every year we will encounter new situations and new problems. These days, we have received some candidates’ consultation in different ways, and put forward some opinions and suggestions to the examination work, from which we can appreciate everyone’s preparation mood.

  Please believe that on your way to your dreams, there is the care of the party and the country and countless people are escorting you. Under the guidance and support of the Ministry of Education, under the leadership of the Shanghai Municipal Party Committee and the Municipal Government, we will work together with all relevant units to make the greatest efforts to achieve "taking the exam as scheduled, taking all the exams, and studying the exam safely", making overall plans for epidemic prevention and control and organizing the exam, making every effort to make all the preparations for the exam, and striving to give you the most attentive and warm security guard. Here, I sincerely hope that every candidate will give more understanding and support to our work.

  In order to help you take the exam smoothly, we have compiled the "Guide to Taking the Exam", which is attached with the letter. Please read it carefully. At the same time, I would like to remind all candidates:

  Candidates who take part in this postgraduate examination must complete a nucleic acid sampling in this city before 12:00 a.m. on the 21st. Relevant departments have made careful arrangements to ensure that candidates can be "single-person and single-tube" when they show their admission tickets, giving priority to the inspection and getting the results as soon as possible. Considering that some candidates in Shanghai are currently at home, the relevant departments will arrange for candidates to go out to take the exam smoothly during the exam. Candidates who return to Shanghai from other places to take the exam can stay in relevant hotels with their identity certificates.Candidates are advised to reduce unnecessary walking and do personal protection during preparation and examination. The test center school will try its best to provide drinking water, medical care and other services for candidates. If candidates have special needs, please take the initiative to contact the test center.

  There are always some beautiful things on the road of life that deserve our all-out efforts. It is never an exam that determines the fate of your life, but every challenge you laugh at, every persistence you persevere in, and every dream you pursue without regret.

  These days, the temperature in Shanghai has fallen below zero, but the sun is still warm on the shoulders. All the past is a preface, and the infinite future is waiting for you to write.

  May you work hard and move forward bravely, and live up to your youth and dreams!

  This time, we stick to it together and come on!

  Shanghai Education Examinations Institute

  December 20, 2022

  A Guide for Candidates Taking the 2023 Postgraduate Examination in Shanghai

  As the entrance examination is just around the corner, please carefully read the examination epidemic prevention tips issued by the Municipal Education Examinations Institute on December 9 and 16, strictly abide by the epidemic prevention requirements, and go to the examination safely. The following reminders are also required for candidates:

  Reminder 1: Do a good job in personal health management before the exam.

  According to the latest epidemic prevention requirements of the city’s research and examination, candidates must do a good job of self-health monitoring before the exam, reduce gathering and mobility, do not go to crowded places, and be the first person responsible for health and safety.All candidates who take part in the postgraduate examination in Shanghai must complete a "single person and single tube" nucleic acid sampling in this city on the morning of December 21st (please complete it before 12:00 noon, and candidates can take a "single person and single tube" sampling with their admission ticket), and take the nucleic acid test results as admission documents during the examination period (paper version or electronic version is acceptable).Candidates should update their health information in the "Candidate Health Information Registration System" according to their own reality. From December 16th to 24th, each test center in this city will send a warm reminder to the candidates every day through the on-site letter or SMS of China Graduate Admissions Information Network, and ask the candidates to pay close attention to the epidemic prevention requirements and precautions in time.

  Reminder 2: Print the admission ticket in advance.

  Candidates can log in to China Graduate Admissions Information Network (http://yz.chsi.com.cn/) with their online username and password, and download and print the Admission Ticket for the 2023 National Postgraduate Admissions Examination. Please read the instructions and requirements on the admission ticket carefully, keep the admission ticket well, and do not make any marks on it.

  Reminder 3: Check the test center, test center number and seat number.

  From now on, candidates should log on to the websites of the relevant colleges and universities, pay attention to the announcement notice in time, and inquire about the examination places, examination rooms, seats and other information of their respective subjects.It is particularly important to note that because the test center will rearrange the examination room according to the test results of candidates’ nucleic acid on the morning of December 21st, the information of some candidates’ examination room may be adjusted, and the information related to the change of the test center and examination room will be informed to the relevant candidates from the afternoon of December 22nd to the morning of the 23rd through the internal letter of the research website and other channels. Candidates are requested to understand and pay close attention to relevant information.

  Reminder 4: Grasp the exam time.

  The examination time is from December 24th to 25th (8: 30am & mdash; 11:30, 14: 00 pm & mdash; 17:00), individual examination subjects exceeding 3 hours will be held on December 26th. Candidates are not allowed to enter the examination room to take the exam as a subject after 15 minutes, so be sure to be familiar with the location of the test center and the route to the exam in advance, pay attention to the weather and traffic conditions on the day of the exam, and make appropriate arrangements to travel in advance to ensure a smooth exam. Pay special attention to carefully check whether the documents and exam supplies are complete before going out.

  Reminder 5: Take all the documents to take the exam.

  Each exam must be based on the candidate’s valid identity card and the Admission Ticket to enter the examination room. Exam supplies that can be carried include pens or signature pens with black handwriting, 2B pencils, rubber without envelopes, drawing instruments, etc. Chemistry (agriculture) (subject code 315) in the unified examination subject can use a scientific calculator with logarithmic and exponential calculation functions without dictionary storage and programming functions, and calculators are not allowed in other unified examination subjects. Whether the self-propositional subjects of the admissions unit are allowed to use calculators should carefully check the "admissions unit description" on the admission ticket; Draft paper shall be distributed uniformly by the test center.

  Reminder 6: Candidates bring their own lunch.

  In order to avoid the spread of the epidemic caused by the crowd gathering, the test center does not provide lunch during the examination. If candidates need to stay at school for preparation, please bring their own lunch and rest in the area designated by the school. The test center school will try its best to provide drinking water, medical care and other services for candidates. If candidates have special needs, please take the initiative to contact the test center.

  Reminder 7: Actively cooperate with the admission inspection.

  Actively cooperate with the admission safety inspection and identity verification, and if you carry any articles other than those specified, you should put them in the designated location according to the regulations; If the security equipment gives an alarm during the inspection, you should consciously show the relevant metal objects to the invigilator. For the convenience of quick inspection, try not to carry (wear) metal objects or clothes. Do not bring any books, periodicals, newspapers, manuscript papers, pictures, materials, tools with communication functions (such as mobile phones, photographic equipment, scanning equipment, intelligent equipment, etc.) or electronic products with storage, programming and inquiry functions, correction fluid, correction tape and other items into the examination room. Special reminder: it is strictly forbidden to bring mobile phones into the examination room. Once found, they will be dealt with in violation of regulations regardless of whether they are turned on or not.

  Reminder 8: Abide by the rules of the examination room.

  Each test center will do its utmost to create a safe and suitable test environment for candidates, provide consultation and medical services, and provide reasonable convenience for special candidates such as the disabled. Candidates are also requested to actively cooperate and abide by the test center management and examination room rules.

  After the test signal is issued, candidates can begin to answer questions; After the end of the exam signal is issued, you should immediately stop writing and stop answering questions; Raise your hand to ask questions such as papers, answer sheets, answer sheets, etc., or unclear handwriting, missed printing, reprinting, and missing pages. But questions involving the content of the test questions shall not be asked by the invigilator. Special reminder not to take the test paper, answer sheet and draft paper out of the examination room, otherwise it will be dealt with in violation of regulations.

  Reminder 9: Pay attention to the exam details.

  Candidates should fill in (paint) the name, candidate number and other information accurately and clearly at the designated location and within the specified time, and paste the bar code as required. Candidates should bear the responsibility for missing the bar code, filling (painting), filling (painting) or illegible answers that affect the marking results.

  Candidates should answer questions outside the sealed line of the answer sheet or in the area specified in the answer sheet; Do not use pens and paper outside the regulations to answer questions, and the answers written on draft paper or outside the prescribed area will be invalid; Do not make any marks on the answer sheet or answer sheet. Only pens of the same type and color can be used in the process of answering questions. When answering the question, be sure to read the question number mark on the answer sheet before answering the question. Anyone who does not answer the question in the correct position will bear the consequences.

  Unified examination subjects, examination papers by the invigilator unified unpacking and distribution, answer sheet (card) by the invigilator unified recycling. Enrollment units from the proposition subjects, by the candidates themselves unpacked test bags and sealed test bags, answer sheets and sealed seals issued by the test center; After the exam, the examinee will put the test paper and answer sheet into the sealed bag.

  Reminder 10: Take the exam in good faith.

  The examination room is equipped with a video monitoring system, and every move of each candidate is recorded in the whole process. During the examination, the departments of education, public security, internet communication and radio management will rectify the environment in and around the examination room, severely investigate and punish those suspected of cheating by using communication tools, and investigate criminal responsibility for suspected crimes. According to the Criminal Law Amendment (IX) of People’s Republic of China (PRC), criminal acts such as "cheating in organizing exams", "illegally selling, providing test questions and answers" and "substituting for exams" will be severely punished by the criminal law. Please take the exam in good faith, abide by the law and discipline, and don’t regret it for life because of temporary luck!

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Research progress in maize one-way cross incompatibility in Institute of Genetic Development

  Corn is one of the crops with the largest sown area and the highest yield in China. Corn has a wide range of uses, not only as feed, but also for various industrial purposes, and provides high-quality protein and starch for human beings. The natural outcrossing rate of maize is as high as 95%, so hybrid seed production and special maize production need to be strictly separated. Conventional time and space isolation measures are time-consuming, laborious and difficult. How to realize corn non-isolated production in a scientific way is an urgent production problem. In general, both self-pollination and hybridization of maize can bear fruit, but there is a phenomenon that a few maize do not accept other maize pollen in nature, which is called unilateral cross-incompatibility (UCI) of maize. Some studies have reported three UCI loci, Ga1, Ga2 and Tcb1, which are composed of pollen and filament determinants respectively. According to the structure and function of UCI loci, maize in nature can be divided into three types: S type (Ga1-S, Ga2-S and Tcb1-S), which contains both pollen and filament determinant genes; M-type (Ga1-M, Ga2-M and Tcb1-M) only contains pollen determinant genes; Common types (ga1, ga2 and tcb1) contain neither pollen nor filament determinant gene. UCI controls the sexual transmission direction of haploid gametes and can be used for reproductive isolation between different types of maize. 
  Chen Huabang, research group of Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, devoted himself to the study of maize one-way cross incompatibility, and reported the pollen and filament factor genes at Ga1 and Ga2 loci and their applications successively (Zhang et al., 2012;; Zhang et al., 2018,Chen et al., 2022; Cai et al., 2022)。 Recently, the team has once again made important progress in the study of maize incompatibility. In this study, the pollen determinant Tcb-m at Tcb1 locus was cloned. This is the "last" cloned determinant gene of maize incompatibility system. So far, all the key determinants of the three incompatibility sites have been cloned and verified, which laid the foundation for the study of commonness and specificity among maize incompatibility systems. On November 16th, related research results were published online in Plant Biotechnology Journal with the title of A Pollen Expressed PME Gene at TC B1 Locus Confers Maize Independent Cross-in Compatibility. 
  It was found that the pollen factor Tcb1-M at TCB1 locus of maize encoded Pectin Methylesterases (PME), which was specifically expressed in the pollen of Tcb1-S materials. Studies have shown that the expression of Tcb1-m gene in common corn by transgenic method can make it pollinate and bear fruit for Tcb1-S type materials. Tcb1 locus and Ga1 locus are closely linked, and their pollen and filament factors are highly similar, and the two loci are in tandem repetitive relationship. However, Tcb1 locus only exists in the primitive ancestor of maize, and Ga1 locus exists in both maize and maize, which indicates that the two loci have differentiated and produced specificity after maize domestication. There are also a certain number of materials containing Ga1 or Ga2 loci in common corn in nature, which will reduce the application value of UCI loci in corn. In this study, the materials containing three sites were combined in different forms, and a polymer material containing two or three incompatible sites was created, which not only effectively hindered the pollen of ordinary corn, but also effectively prevented the risk of penetration of materials containing a single incompatible site, and further improved the application of corn incompatibility in non-isolated seed production. This study laid a material foundation for the mechanism analysis of incompatible systems. 
  The research work is supported by the National Natural Science Foundation of China. 
  Cloning and application of pollen factor gene at Tcb1 locus in maize 

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Pigskin is made into corneas to restore vision for the blind without waiting for donations.

usepigskinThe cornea can restore the vision of visually impaired patients.

really? ? ?

Yes, this study was recently published in Nature Biotechnology, a sub-journal of Nature, and a pilot study has been carried out, which has restored the vision of 20 patients without adverse reactions.

In the world, there are as many as 12.7 million people who are sick or even blind because of corneal damage. At present, the most common method is to transplant corneas donated by human beings, but only one in every 70 patients can get a corneal transplant.

Moreover, patients who need corneal transplantation often gather in low-income and middle-income countries or regions, and the opportunities for treatment are very limited.

At this time, the pig came, and the pig came with its powerful effect.

However, when it comes to pigskin, few people associate it with cornea. How are they related?

Using collagen molecules from pigskin

One of the main components of cornea is collagen. By extracting collagen molecules from pigskin, researchers developed a collagen-based corneal matrix substitute: Bioengineered Porcine Construction (Double Crosslinked for short: BPCDX).

Corneal implant made of collagen in pig skin

How exactly is it done?

Firstly, after extracting collagen from pigskin, it was purified and freeze-dried.

Collagen was then dissolved in sterile phosphate buffered saline (PBS) at room temperature to form a 5% collagen solution.

Next, a new vacuum evaporation technology is used, which can controllably achieve high collagen content (12-18%). In the past, the weight of collagen in human test implants was limited to 10% (the natural human corneal collagen content was 13.6%).

However, pure collagen is a soft material which is easy to degrade. In order to solve this problem, researchers used two chemical crosslinks to finally form a transparent implantable hydrogel, which improved the mechanical strength, degradation resistance and long-term stability of the implant.

But is it reliable to use pigskin to make cornea and treat visually impaired patients?

In this regard, the researchers also conducted a series of clinical trials, and they conducted feasibility studies in India and Iran.

The researchers implanted BPCDX in 20 visually impaired patients to reshape the native corneal stroma without removing existing tissues or using sutures.

During the two-year follow-up, no adverse phenomena were observed.

As can be seen from the table, 14 legally blind people before operation were not judged to be blind after operation. Moreover, all subjects in the two queues were intolerant of contact lenses before operation, but they could tolerate wearing contact lenses for a long time at 24 months after operation.

Judging from the effect of clinical trial, this is not an unreliable technology, but it sounds very complicated. Can ordinary patients afford it?

Low cost, easy storage and minimally invasive.

Mehrdad Rafat, an associate professor of biomedical engineering, said:

We do a lot of research to ensure that this technology is affordable for everyone, not just the rich.

In this technology, pigskin used in extracting collagen is a by-product of food industry, which is easy to obtain and the cost is not very high.

In addition, researchers have developed compatible packaging and sterilization processes, so that bioengineered corneas can be stored for up to two years before use, so that they can be provided to different regions and even rural areas without biological banks or storage tissue preparation facilities.

It is worth mentioning that the cornea made of pigskin does not need to remove the patient’s own tissue when treating visually impaired patients, but instead, it is a small incision through which the implant is inserted into the existing cornea.

And this new surgical method does not need suture, but uses advanced laser surgery to make corneal incision with high precision, and then uses simple surgical instruments to perform it manually when necessary.

It costs less and is minimally invasive, so when will this technology be popularized?

Not yet!

Before using implants in medical care, it is necessary to conduct larger-scale clinical research and obtain market approval from regulatory agencies.

In addition, researchers also want to study whether this technology can be used to treat more eye diseases, and whether implants can be adapted to individuals to obtain greater curative effects.

One More Thing

In fact, in 2016, there was a successful case of bioengineered corneal transplantation in South China. A 14-year-old boy from Jiangxi chose bioengineered membrane transplantation. After a week of treatment, his vision reached 0.1.

Source: Southern Metropolis Daily

However, this operation uses a rarer pig cornea, and this study of Nature is to extract collagen from pig skin to make a corneal substitute. In contrast, the latter has greater application potential.