标签归档 西安高端外卖

usepigskinThe cornea can restore the vision of visually impaired patients.

really？ ? ?

Yes, this study was recently published in Nature Biotechnology, a sub-journal of Nature, and a pilot study has been carried out, which has restored the vision of 20 patients without adverse reactions.

In the world, there are as many as 12.7 million people who are sick or even blind because of corneal damage. At present, the most common method is to transplant corneas donated by human beings, but only one in every 70 patients can get a corneal transplant.

Moreover, patients who need corneal transplantation often gather in low-income and middle-income countries or regions, and the opportunities for treatment are very limited.

At this time, the pig came, and the pig came with its powerful effect.

However, when it comes to pigskin, few people associate it with cornea. How are they related?

Using collagen molecules from pigskin

One of the main components of cornea is collagen. By extracting collagen molecules from pigskin, researchers developed a collagen-based corneal matrix substitute: Bioengineered Porcine Construction (Double Crosslinked for short: BPCDX).

How exactly is it done?

Firstly, after extracting collagen from pigskin, it was purified and freeze-dried.

Collagen was then dissolved in sterile phosphate buffered saline (PBS) at room temperature to form a 5% collagen solution.

Next, a new vacuum evaporation technology is used, which can controllably achieve high collagen content (12-18%). In the past, the weight of collagen in human test implants was limited to 10% (the natural human corneal collagen content was 13.6%).

However, pure collagen is a soft material which is easy to degrade. In order to solve this problem, researchers used two chemical crosslinks to finally form a transparent implantable hydrogel, which improved the mechanical strength, degradation resistance and long-term stability of the implant.

But is it reliable to use pigskin to make cornea and treat visually impaired patients?

In this regard, the researchers also conducted a series of clinical trials, and they conducted feasibility studies in India and Iran.

The researchers implanted BPCDX in 20 visually impaired patients to reshape the native corneal stroma without removing existing tissues or using sutures.

During the two-year follow-up, no adverse phenomena were observed.

As can be seen from the table, 14 legally blind people before operation were not judged to be blind after operation. Moreover, all subjects in the two queues were intolerant of contact lenses before operation, but they could tolerate wearing contact lenses for a long time at 24 months after operation.

Judging from the effect of clinical trial, this is not an unreliable technology, but it sounds very complicated. Can ordinary patients afford it?

Low cost, easy storage and minimally invasive.

Mehrdad Rafat, an associate professor of biomedical engineering, said:

We do a lot of research to ensure that this technology is affordable for everyone, not just the rich.

In this technology, pigskin used in extracting collagen is a by-product of food industry, which is easy to obtain and the cost is not very high.

In addition, researchers have developed compatible packaging and sterilization processes, so that bioengineered corneas can be stored for up to two years before use, so that they can be provided to different regions and even rural areas without biological banks or storage tissue preparation facilities.

It is worth mentioning that the cornea made of pigskin does not need to remove the patient’s own tissue when treating visually impaired patients, but instead, it is a small incision through which the implant is inserted into the existing cornea.

And this new surgical method does not need suture, but uses advanced laser surgery to make corneal incision with high precision, and then uses simple surgical instruments to perform it manually when necessary.

It costs less and is minimally invasive, so when will this technology be popularized?

Not yet!

Before using implants in medical care, it is necessary to conduct larger-scale clinical research and obtain market approval from regulatory agencies.

In addition, researchers also want to study whether this technology can be used to treat more eye diseases, and whether implants can be adapted to individuals to obtain greater curative effects.

One More Thing

In fact, in 2016, there was a successful case of bioengineered corneal transplantation in South China. A 14-year-old boy from Jiangxi chose bioengineered membrane transplantation. After a week of treatment, his vision reached 0.1.

However, this operation uses a rarer pig cornea, and this study of Nature is to extract collagen from pig skin to make a corneal substitute. In contrast, the latter has greater application potential.

Every reporter | Sun Lei Li Xing every editor | Fan Wenqing Pei Jianru Lu Xiangyong　　　　

Tesla’s price reduction at the beginning of this year was a "fierce drug", which put pressure on a number of new domestic car companies. It is reported that Tesla China won an order for 30,000 new cars within three days after the official announcement of price reduction on January 6, 2023.

On February 1, a number of new energy automobile companies announced the delivery of new cars in January 2023. From the data point of view, at the beginning of the new year, the "national subsidy" for new energy vehicles that lasted for 13 years officially stopped. Most new energy vehicle companies generally experienced an expected decline in January, but some car companies significantly exceeded expectations. Among them,Only one new car-making force has achieved a monthly delivery of over 10,000 vehicles.

Watchmaking: Every reporter Sun Lei

The new forces are only ideal over 10,000, and the zero run is reduced by 80%.

Specifically, LI still maintained a strong momentum. Although it failed to deliver more than 20,000 vehicles per month again, it still ranked first in the new car delivery list of the new car-making forces in that month. Data show that in January, LI delivered a total of 15,100 new cars, up 23.4% year-on-year. Since the delivery, the cumulative delivery volume in LI has reached 272,500 vehicles.

LI said that as of January 31, 2023, LI had 296 retail centers nationwide, covering 123 cities; There are 320 after-sales maintenance centers and authorized car body panel spraying centers, covering 222 cities. In addition, the new car ideal L7 will be officially released on February 8, 2023.

Image source: Photo courtesy of the enterprise

After LI, Weilai delivered 8,506 new cars in January 2023, including 2,190 high-end intelligent electric SUVs and 6,316 high-end intelligent electric cars. As of January 31, 2023, Weilai has delivered a total of 298,000 vehicles.

Nezha ranked third, delivering 6,016 new cars in January, down 45.4% year-on-year. Among them, 3,487 vehicles were delivered by Nezha V, 1,012 vehicles by Nezha U and 1,517 vehicles by Nezha S. As of January this year, Nezha has delivered a total of 254,000 vehicles.

Image source: Every reporter Zhang Jianshe (data map)

Xpeng Motors delivered 5,218 new cars in January, of which G9 delivered 2,249. Xpeng Motors said that the change in delivery data was due to the delay of some deliveries during the Spring Festival, and the monthly delivery volume reflected the seasonal slowdown of the Spring Festival holiday since mid-January.

Image source: Every photo by reporter Zhu Wanping (data map)

National business daily reporter learned that the newly redesigned Tucki intelligent coupe P7 will be unveiled in the near future. According to the plan, Xpeng Motors will have two new cars on the market in 2023, and replace the existing three old models, with the goal of delivering 200,000 vehicles throughout the year.

In January, the fifth place in the new car delivery list of the new forces was the zero-running car. It is worth noting that,Zero-run cars have been going downhill since the IPO, with only 1,139 vehicles delivered in January, a sharp drop of over 80% from the previous month.The zero-run car announced that the C11 extended-range version of the zero-run car will be pre-sold on February 9 this year.

In terms of new car brands of traditional car companies, the latest sales data released by Ai ‘an showed that its sales volume in January was 10,200, but it was 36.3% lower than the same period last year. On February 1st, GAC Aian announced that the new version of AION S Plus, 70 Lexiang Edition, was officially launched, with a price of 149,800 yuan, with a view to accelerating the sales target of 500,000 vehicles in 2023.

Watchmaking: Every reporter Sun Lei

According to the delivery data released by AITO brand, the delivery volume of the series in January reached 4,475 vehicles, and more than 80,000 vehicles have been delivered. It is worth mentioning that at the beginning of January, AITO officially announced that some models of its M5 and M7 cars would be adjusted in price. Among them, the adjusted price of Wujie M5 EV starts from 259,800; After adjustment, the price of the M7 in Wenjie started at 289,800.

It is worth mentioning that, after the price adjustment, the price of the M5 EV has been the same as the starting price of its extended-range model. In the past, due to the cost of raw materials, the price of the pure electric version of the same model was generally higher than that of the extended-range or plug-in hybrid version. For example, the starting price of the pure electric model of Changan Deep Blue SL03 was 189,900 yuan, while the starting price of the extended-range model was 171,900 yuan. The starting price of BYD Han EV is 2000 yuan higher than that of Han DM model.

Is the hybrid market also "lying down"?

Some people think that as Tesla, Tucki and AITO reduce the price of their pure electric vehicles, the market popularity of extended-range or plug-in hybrid vehicles may be affected. According to the data of the Federation, in 2022, the cumulative retail volume of domestic PHEV models was about 1.42 million, up 160.5% year-on-year, and the growth rate was better than that of pure electric vehicles and the market.

However, there are also views that with the expansion of the market scale, the supply of range extenders, hybrid engines, reducers and other components carried by extended-range or plug-in hybrid vehicles has formed a scale effect, and it has a certain price adjustment space. On the other hand, due to the particularity of vehicle structure, the cost of power battery is not high in extended-range or plug-in hybrid vehicles, which also enables it to better cope with risks such as cost fluctuation of raw materials related to power battery.

Image source: AITO auto official micro-screenshot

Yantu Automobile also announced the delivery data in January 2023. The data shows that Lantu Automobile delivered 1,548 new cars in January, down 10.5% from the previous month, and the average transaction price exceeded 382,000 yuan. Lu Fang, CEO of Lantu Automobile, said: "In January, it was the Spring Festival holiday, and the daily operation of national sales stores and users’ licensing were greatly affected."

In addition, 3,116 new cars were delivered in January, a year-on-year decrease of about 12%. On January 10, Extreme Krypton said that the Extreme Krypton Smart Factory will use the Spring Festival holiday and the period before and after it to upgrade its production line. It is estimated that the time for upgrading the equipment production line will be from January 11 to February 1, 2023.

It is worth noting that,BYD’s sales of new energy vehicles remained bright in January, with a sales volume of 151,300 vehicles, a year-on-year increase of 62.44%.Among them, the sales volume of pure electric passenger cars was 71,300, a year-on-year increase of 53.79%; There were 78,800 plug-in hybrid passenger cars, a year-on-year increase of 69.37%.

Image source: Every photo by reporter yan wang

BYD’s Tengshi brand continued to grow, with sales of 6,439 vehicles in January, up 7.3% from the previous month. Among them, the average transaction price of Tengshi MPV D9 was 410,000 yuan, which also broke the old pattern of foreign brands dominating the traditional luxury MPV market. It is reported that since its listing, the cumulative order volume of Tengshi D9 has exceeded 50,000 vehicles.

According to the data released by the Association, the retail sales volume of narrow passenger cars in January is expected to be 1.36 million, down 34.6% year-on-year and 37.3% quarter-on-quarter. Among them, the retail sales volume of new energy is expected to be 360,000 vehicles, with a year-on-year increase of 1.8%, a month-on-month decrease of 43.8% and a penetration rate of 26.5%. According to the analysis of the Federation, in January, under the influence of factors such as pre-consumption, epidemic distribution and early Spring Festival, the growth rate of the automobile market declined.

At the beginning of the new year in 2023, the subsidy for new energy vehicles that has been implemented for 13 years has withdrawn from the historical stage. The so-called subsidy refers to the purchase of qualified new energy vehicles, which can get a one-time subsidy. In 2010, the Ministry of Finance began to pilot subsidies for privately purchased new energy vehicles, and in 2013, a unified national subsidy standard was officially introduced. After that, for more than ten years, the subsidy standard was 60,000 yuan for buying a new energy vehicle at the beginning, and finally the benefit amount was reduced to 10,000 yuan. According to the latest statistics released by the Ministry of Industry and Information Technology, from the beginning of the policy in 2010 to 2020, the subsidy for new energy vehicles has exceeded 152.1 billion yuan, covering at least 3.17 million vehicles.

Cui Dongshu, secretary general of the National Passenger Car Market Information Association, believes that the sales growth of new energy vehicles has entered a bottleneck stage, and it will be a serious problem after the new energy subsidy policy is withdrawn from the market in 2023. "The price increase of new energy vehicles in the early stage was too high, and the orders were less. Then the price reduction of head enterprises such as Tesla was superimposed, which caused consumers’ wait-and-see mood, and the sales volume dropped significantly from the previous month." Cui Dongshu said.

Weilai’s highest discount is over 100,000? Official response

On February 2, some media reported that Wei Lai (09866.HK)The price reduction promotion was started for the 2022 ES6 and ES8 models, with a maximum drop of over 100,000 yuan.

"The 2022 ES8, ES6 and EC6 are about to usher in a new generation of models.At present, there are still a small number of exhibition cars and stock cars available for sale, and these vehicles can enjoy the exhibition car policy.. In response to the above news, the relevant person in charge of Weilai replied to the reporter of national business daily.

However, the report said that the maximum decline of over 100,000 yuan has not been clearly confirmed by Weilai. The above-mentioned person in charge of Weilai only explained that Weilai Japan often has replacement policies, financial policies and technology configuration packages for users to choose from. At present, it is still valid for 2022 ES8, ES6 and EC6 models, among which financial policies are more favorable to car buyers. "The 2022 ES8, ES6 and EC6 models are equipped with 8155 intelligent cockpit chips and Alder intelligent system, and they are still very competitive intelligent electric vehicle products on the market. Weilai will update and maintain the Alder intelligent system software for a long time." The relevant person in charge of Weilai said.

According to the above media reports, the 2022 ES8 and ES6 can still enjoy the subsidy of over 10,000 yuan from Weilai for national new energy vehicles, and the loan has zero interest and zero handling fee for three years. If the old car is replaced in Weilai, Weilai will also give a replacement subsidy of 15,000 yuan. If it is a vehicle with an inventory cycle of more than 120 days, not only can you enjoy a cash discount of up to 40,000 yuan, but Weilai also presents a worry-free service package (including commercial insurance) worth over 10,000 yuan to the owner. In addition, for the promotion of the 2022 ES6 and ES8, Weilai also directly presented NIO Pilot complete package worth 39,000 yuan. If users choose 4,900 yuan NOMI and 6,500 yuan augmented reality, Weilai can also give a discount of 9,600 yuan directly.

Image source: Wei Lai official website

In December last year, Qin Lihong, co-founder and president of Weilai, told reporters that before June 2023, Weilai would complete the iteration of the full range of ES8, ES6 and EC6 models to NT2.0 platform. At the "NIO Day2022" held in December last year, Weilai built a replacement model based on the second generation technology platform NT2.0 — — The new ES8 has been released to the public, and it is planned to start delivery in June this year.

The reporter checked Weilai official website, APP, etc. and found that the specific preferential sales plan for the 2022 ES8, ES6 and EC6 model exhibition cars and stock cars has not been announced. As for the opening time of the price reduction promotion activities of the above three replacement models, Wei Lai has not responded as of press time.

According to the previously disclosed plan, in the first half of 2023, Weilai will launch five new models. By June, 2023, Weilai will have 8 models on sale simultaneously, among which three models are the new generation models of ES8, ES6 and EC6.

Image source: Every photo by reporter Zhu Wanping (data map)

Li Bin, chairman of Weilai, made it clear at the "NIO Day2022" media meeting that it is expected that by the fourth quarter of next year, the outside world will see the sales potential of Weilai’s entire second-generation platform product portfolio.

Reporter |Sun Lei Li Xing　Edit |Fan Wenqing Pei Jianru Lu Xiangyong Du Hengfeng

Proofread |Sun Zhicheng

| national business daily 　nbdnews　　Original article |

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　Zhengzhou Liujiang Animal Husbandry "Yishan Yilin" direct sales stores

　　Liujiang animal husbandry "relying on mountains and forests" claims to be an ecological grazing in organic eggs.

　　Zhengzhou, China Food Network, September 3rd (trainee reporter Qiu Liangjing He Dao) Liujiang Animal Husbandry in Henan claimed that organic eggs could sell the "golden egg price", and the price of Liujiang Animal Husbandry eggs was one more than that of 6 yuan, which was more than 10 times higher than that of ordinary eggs in the market. On September 2nd, Zhengzhou Municipal Price Bureau said in an interview with China Food Network that although the price of eggs can be sold by enterprises at their own prices, it does not mean that enterprises can bid all over the sky, and the price should be supervised and managed by industrial and commercial departments and food quality inspection departments. If there is any act of raising prices by false propaganda and deceiving consumers, in violation of the relevant provisions of the price law, corresponding management and punishment will be given according to the provisions on administrative penalties for prices.

　　"Adhere to forest stocking, adopt organic food and raise organic eggs ecologically", and Henan Liujiang Ecological Animal Husbandry Company claims that it has created a "villa-style" ecological raising of laying hens in China. Chickens eat natural cordyceps, whole grains, listen to music and live in five-star villas. However, the media reported that Liujiang animal husbandry not only used a variety of feed additives in laying hens, but also failed to achieve ecological grazing.

　　A few days ago, some media reported that Liujiang animal husbandry used feed containing additives to improve its quality, with more than 10 kinds of additives. Liujiang Animal Husbandry responded that additives such as calcium hydrogen phosphate, ferrous sulfate, copper sulfate, manganese sulfate, zinc sulfate, sodium bicarbonate and potassium chloride all meet the requirements of the Catalogue of Feed Additives (2008) and are suitable for animal breeding.

　　It is understood that Liujiang Animal Husbandry Co., Ltd. owns two egg brands, namely "Liujiang" and "Yishan Yilin". According to its product introduction, it adopts low-density grazing, an ecological grazing farm derived from ten thousand mu of natural forest, and adopts organic food. Chickens dig the soil freely for food, eat natural insects and weeds, organic soybean corn and organic packages carefully prepared by Astragalus, dried tangerine peel and honeysuckle.

　　On August 31, the reporter found in the direct store of "Yishan Yilin" in Liujiang Animal Husbandry, Zhengzhou City that the price of a 32-box "Yishan Yilin" was 128 yuan, with an average price of 4 yuan/piece; "Yishan Yilin" Supreme -36 series ecological eggs, the price of 32 eggs is 198 yuan, with an average price of 6.18 yuan/piece. Why is the price of the same 32-piece package so different? A person in charge of the store said: "The stocking density is different, and the stocking density with high price is lower. There are fewer chickens per mu, and the natural Cordyceps obtained by chickens is richer, and the nutritional value of the eggs laid is definitely higher. The eggs do not contain any additives and hormones, which is more beneficial to human health."

　　The reporter found that the store is currently promoting the sale of a "organic eggs for pregnant and baby". The staff of the store told the reporter: "organic eggs for pregnant and baby" is not for retail, and consumers can only buy it with an annual card. The annual fee for each card is 1580 yuan, and a total of 930 "organic eggs for pregnant and baby" can be purchased. Consumers with annual cards can call the manufacturer to deliver the goods at any time.

　　Insiders pointed out that some farms use ordinary eggs as high-priced nutritious eggs, which have no certain safety indicators and are difficult to distinguish from color and size. Ordinary consumers can’t distinguish them. From the perspective of nutritional composition, they are not much different from ordinary eggs. These conceptual eggs covered with gorgeous coats are mostly fools. The profit of ordinary eggs is very thin, but after wearing a nutritious "hat", the "worth" will rise. The so-called nutrition and nature are actually a gimmick made by merchants.

　　It is understood that there are two standards for eggs in China, namely "Hygienic Standard for Fresh Eggs" and "Standard for Pollution-free Eggs", but both standards are regulated from the perspective of food safety. Among them, the limit standards are set for toxic and harmful substances such as antibiotics, heavy metals and pesticides in eggs. As of press time, Liujiang Animal Husbandry also failed to provide relevant inspection report to the reporter of China Food Network, proving that the nutritional value of Liujiang Animal Husbandry Eggs is higher than that of ordinary eggs.

　　According to the official website of Liujiang Animal Husbandry, the company’s chickens live in a "five-star villa", drink filtered pure water, eat natural Cordyceps and organic set meals, are accompanied by roosters, and lay eggs in music. There are 100,000 high-quality laying hens in stock, which can produce 20 million pieces of organic eggs every year, and most of them are sold to large supermarkets such as Dennis, Wal-Mart, Carrefour and Century Lianhua.

　　Earlier, some media reported that Liujiang animal husbandry used feed containing additives to improve its quality. There were more than 10 kinds of additives, including prohibited additives explicitly prohibited by the state. After the media reports, the animal husbandry department of Jiyuan City, Henan Province supervised and monitored the feed factory and laying hen production field of Liujiang Company in Henan Province, and will inform them in time after the results come out. However, as of press time, Jiyuan animal husbandry department did not inform the media about the supervision and monitoring of Liujiang animal husbandry.

　　In fact, enterprises that use the concepts of cordyceps eggs, native eggs, whole grain eggs and ecological eggs to promote their products have to mention Zhejiang Aerospace Agricultural Science and Technology Co., Ltd.. As early as March this year, the "Aerospace Village" earth eggs produced by the company were advertised as "natural environment grazing, eating grass, insects and other foods", but some of the earth eggs and stupid eggs came from farms and were fed with feed and antibiotics. The price can be about twice as high as that of ordinary fresh eggs. After media reports, Hangzhou Industrial and Commercial Department was suspected of false propaganda of "Yuhang Village" and asked it to change its packaging within the time limit. At the same time, various supermarkets in Hangzhou have taken off the "Aerospace Village" earth eggs. Since the "Aerospace Village" earth eggs were removed from the shelves, this brand of eggs has never appeared in the market again.

　　Is it normal that the price of eggs raised in Liujiang animal husbandry is more than ten times higher than that in the market? On September 2nd, a staff member surnamed Chen of Zhengzhou Price Bureau said in an interview with a reporter from China Food Network that although the price of eggs can be sold at their own prices, it does not mean that enterprises can bid all over the sky, and the price still needs to be supervised and managed by the industrial and commercial departments and the food quality inspection departments. If there is any act of raising prices by false propaganda and deceiving consumers, in violation of the relevant provisions of the price law, corresponding management and punishment will be given according to the provisions on administrative penalties for prices.

　　Organic eggs of Liujiang Animal Husbandry is really higher in nutritional value than ordinary eggs, its egg price is more than ten times higher than the market egg price, how the regulatory authorities will handle it, and whether its egg output is consistent with the sales volume, etc., China Food Network reporter will continue to pay attention. (End)